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PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D [ Homo sapiens (human) ]

Gene ID: 8493, updated on 26-Aug-2014
Official Symbol
PPM1Dprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1Dprovided by HGNC
Primary source
HGNC:9277
See related
Ensembl:ENSG00000170836; HPRD:05482; MIM:605100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WIP1; PP2C-DELTA
Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
See PPM1D in Epigenomics, MapViewer
Location:
17q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (60600183..60666280)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (58677544..58743641)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein (cytoplasmic tail) binding protein 2 Neighboring gene uncharacterized LOC388406 Neighboring gene ribosomal protein L36a pseudogene 46 Neighboring gene breast carcinoma amplified sequence 3 Neighboring gene transfer RNA suppressor (TTA) 1-1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to radiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
protein phosphatase 1D
Names
protein phosphatase 1D
protein phosphatase Wip1
wild-type p53-induced phosphatase 1
protein phosphatase 2C delta isoform
protein phosphatase 1D magnesium-dependent, delta isoform
NP_003611.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023265.1 

    Range
    4991..71088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_770

mRNA and Protein(s)

  1. NM_003620.3NP_003611.1  protein phosphatase 1D

    See proteins identical to NP_003611.1

    Status: REVIEWED

    Source sequence(s)
    AC110602, BC060877, BU616782, U78305
    Consensus CDS
    CCDS11625.1
    UniProtKB/Swiss-Prot
    O15297
    Related
    ENSP00000306682, OTTHUMP00000263204, ENST00000305921, OTTHUMT00000449474
    Conserved Domains (1) summary
    cd00143
    Location:91375
    Blast Score: 557
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    60600183..60666280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    54048263..54112992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    58742292..58808407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)