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    Dicer1 dicer 1, ribonuclease type III [ Mus musculus (house mouse) ]

    Gene ID: 192119, updated on 26-Jul-2015
    Official Symbol
    Dicer1provided by MGI
    Official Full Name
    dicer 1, ribonuclease type IIIprovided by MGI
    Primary source
    MGI:MGI:2177178
    See related
    Ensembl:ENSMUSG00000041415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Ertd7e; mKIAA0928; 1110006F08Rik
    Orthologs
    See Dicer1 in Epigenomics, MapViewer
    Location:
    12 54.83 cM; 12 E-F1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (104687740..104751952, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (105925952..105990162, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10000 Neighboring gene predicted gene, 31573 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene calmin Neighboring gene predicted gene, 40563 Neighboring gene spectrin repeat containing, nuclear envelope family member 3 Neighboring gene predicted gene, 31742

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    endoribonuclease activity, producing 5'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    pre-miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to pre-miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribonuclease III activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribonuclease III activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    ribonuclease III activity ISO
    Inferred from Sequence Orthology
    more info
     
    siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA phosphodiester bond hydrolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA phosphodiester bond hydrolysis, endonucleolytic ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    RNA phosphodiester bond hydrolysis, endonucleolytic ISO
    Inferred from Sequence Orthology
    more info
     
    RNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anatomical structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac neural crest cell development involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    conversion of ds siRNA to ss siRNA ISO
    Inferred from Sequence Orthology
    more info
     
    conversion of ds siRNA to ss siRNA involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intestinal epithelial cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    miRNA loading onto RISC involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast differentiation involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Schwann cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    olfactory bulb interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peripheral nervous system myelin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Schwann cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    production of siRNA involved in RNA interference IDA
    Inferred from Direct Assay
    more info
    PubMed 
    production of siRNA involved in RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    production of siRNA involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Notch signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    regulation of RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of enamel mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    siRNA loading onto RISC involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    targeting of mRNA for destruction involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    zygote asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    micro-ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    endoribonuclease Dicer
    Names
    Dicer1, Dcr-1 homolog
    double-strand-specific ribonuclease mDCR-1
    NP_683750.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148948.2NP_683750.2  endoribonuclease Dicer

      See identical proteins and their annotated locations for NP_683750.2

      Status: VALIDATED

      Source sequence(s)
      AC124364
      Consensus CDS
      CCDS36539.1
      UniProtKB/TrEMBL
      F8VQ54
      Related
      ENSMUSP00000043676, ENSMUST00000041987
      Conserved Domains (10) summary
      smart00487
      Location:30232
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:435579
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:48199
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00048
      Location:18341896
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd00079
      Location:434543
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00593
      Location:16661830
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      pfam03368
      Location:620712
      Dicer_dimer; Dicer dimerization domain
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

      Range
      104687740..104751952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515611.2XP_006515674.1  

      See identical proteins and their annotated locations for XP_006515674.1

      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (10) summary
      smart00487
      Location:30232
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:435579
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:48199
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00048
      Location:18341896
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd00079
      Location:434543
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00593
      Location:16661830
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      pfam03368
      Location:620712
      Dicer_dimer; Dicer dimerization domain
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    2. XM_006515608.2XP_006515671.1  

      See identical proteins and their annotated locations for XP_006515671.1

      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (10) summary
      smart00487
      Location:30232
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:435579
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:48199
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00048
      Location:18341896
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd00079
      Location:434543
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00593
      Location:16661830
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      pfam03368
      Location:620712
      Dicer_dimer; Dicer dimerization domain
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    3. XM_006515610.2XP_006515673.1  

      See identical proteins and their annotated locations for XP_006515673.1

      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (10) summary
      smart00487
      Location:30232
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:435579
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:48199
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00048
      Location:18341896
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd00079
      Location:434543
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00593
      Location:16661830
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      pfam03368
      Location:620712
      Dicer_dimer; Dicer dimerization domain
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
    4. XM_006515609.2XP_006515672.1  

      See identical proteins and their annotated locations for XP_006515672.1

      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (10) summary
      smart00487
      Location:30232
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:435579
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:48199
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00048
      Location:18341896
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd00079
      Location:434543
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00593
      Location:16661830
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      pfam03368
      Location:620712
      Dicer_dimer; Dicer dimerization domain
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

    Alternate Mm_Celera

    Genomic

    1. AC_000034.1 Alternate Mm_Celera

      Range
      105918245..105982441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)