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ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 [ Homo sapiens (human) ]

Gene ID: 89845, updated on 6-Jul-2014
Official Symbol
ABCC10provided by HGNC
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 10provided by HGNC
Primary source
HGNC:52
Locus tag
RP5-895C5.1
See related
Ensembl:ENSG00000124574; HPRD:07623; MIM:612509; Vega:OTTHUMG00000014733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP7; SIMRP7; EST182763
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
See ABCC10 in Epigenomics, MapViewer
Location:
6p21.1
Exon count :
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (43427544..43450425)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43395282..43418163)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 pseudogene 14 Neighboring gene zinc finger protein 318 Neighboring gene ribosomal protein S2 pseudogene 28 Neighboring gene microRNA 6780b Neighboring gene uncharacterized LOC101929661 Neighboring gene delta-like 2 homolog (Drosophila) Neighboring gene tight junction associated protein 1 (peripheral)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP catabolic process IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
multidrug resistance-associated protein 7
Names
multidrug resistance-associated protein 7
ATP-binding cassette sub-family C member 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198934.1NP_001185863.1  multidrug resistance-associated protein 7 isoform MRP7

    See proteins identical to NP_001185863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MRP7), encodes the longer isoform (MRP7).
    Source sequence(s)
    AK000002, AY032599
    Consensus CDS
    CCDS56430.1
    UniProtKB/Swiss-Prot
    Q5T3U5
    Related
    ENSP00000361608, OTTHUMP00000016438, ENST00000372530, OTTHUMT00000040603
    Conserved Domains (4) summary
    cd03244
    Location:12441463
    Blast Score: 837
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:598801
    Blast Score: 821
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:2191469
    Blast Score: 1038
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:285551
    Blast Score: 232
    ABC_membrane; ABC transporter transmembrane region
  2. NM_033450.2NP_258261.2  multidrug resistance-associated protein 7 isoform MRP7A

    See proteins identical to NP_258261.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (MRP7A), also known as SIMRP7, has multiple differences, compared to variant MRP7. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant MRP7. The encoded protein (isoform MRP7A) is shorter than isoform MRP7.
    Source sequence(s)
    AY032599
    Consensus CDS
    CCDS4896.1
    UniProtKB/Swiss-Prot
    Q5T3U5
    Related
    ENSP00000244533, OTTHUMP00000016441, ENST00000244533, OTTHUMT00000040608
    Conserved Domains (4) summary
    cd03244
    Location:12161435
    Blast Score: 836
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:570773
    Blast Score: 820
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:1761441
    Blast Score: 1038
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:242508
    Blast Score: 231
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    43427544..43450425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715240.1XP_006715303.1  

    Conserved Domains (4) summary
    cd03250
    Location:598801
    Blast Score: 824
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:2191430
    Blast Score: 901
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:285551
    Blast Score: 234
    ABC_membrane; ABC transporter transmembrane region
    cl17201
    Location:12721430
    Blast Score: 553
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain
  2. XM_005249470.1XP_005249527.1  

    Conserved Domains (2) summary
    pfam00664
    Location:285551
    Blast Score: 239
    ABC_membrane; ABC transporter transmembrane region
    cl17201
    Location:598743
    Blast Score: 602
    ABC_ATPase; ATP-binding cassette transporter nucleotide-binding domain

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    43113792..43136645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    43398442..43421307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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