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    LIN28B lin-28 homolog B (C. elegans) [ Homo sapiens (human) ]

    Gene ID: 389421, updated on 19-Jul-2015
    Official Symbol
    LIN28Bprovided by HGNC
    Official Full Name
    lin-28 homolog B (C. elegans)provided by HGNC
    Primary source
    HGNC:HGNC:32207
    See related
    Ensembl:ENSG00000187772; HPRD:13366; MIM:611044; Vega:OTTHUMG00000015290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSDD2
    Summary
    The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
    Orthologs
    See LIN28B in Epigenomics, MapViewer
    Location:
    6q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (104936999..105083332)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (105384874..105531207)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Neighboring gene poly(A) binding protein, cytoplasmic 4 (inducible form) pseudogene Neighboring gene long intergenic non-protein coding RNA 577 Neighboring gene blood vessel epicardial substance Neighboring gene BVES antisense RNA 1 Neighboring gene popeye domain containing 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure.
    NHGRI GWA Catalog
    Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
    NHGRI GWA Catalog
    Genetic variation in LIN28B is associated with the timing of puberty.
    NHGRI GWA Catalog
    Genome wide association study of age at menarche in the Japanese population.
    NHGRI GWA Catalog
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    NHGRI GWA Catalog
    Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
    NHGRI GWA Catalog
    Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.
    NHGRI GWA Catalog
    Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    NHGRI GWA Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog
    Identification of ten loci associated with height highlights new biological pathways in human growth.
    NHGRI GWA Catalog
    Many sequence variants affecting diversity of adult human height.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with lin-28 homolog B (LIN28B) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ16517

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    miRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pre-miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    aggresome IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    protein lin-28 homolog B
    Names
    Lin-28.2
    lin-28B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032815.1 RefSeqGene

      Range
      5001..131285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004317.3NP_001004317.1  protein lin-28 homolog B

      See identical proteins and their annotated locations for NP_001004317.1

      Status: REVIEWED

      Source sequence(s)
      AW674597, DQ127228
      Consensus CDS
      CCDS34504.1
      UniProtKB/Swiss-Prot
      Q6ZN17
      Related
      ENSP00000344401, OTTHUMP00000016909, ENST00000345080, OTTHUMT00000041646
      Conserved Domains (1) summary
      cd04458
      Location:31101
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      104936999..105083332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715477.2XP_006715540.2  

      Conserved Domains (1) summary
      cd04458
      Location:50120
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    2. XM_011535818.1XP_011534120.1  

      Conserved Domains (1) summary
      cd04458
      Location:39109
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      105666790..105793230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)