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polA 5' to 3' DNA polymerase and 3' to 5'/5' to 3' exonuclease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948356, updated on 18-Jan-2015
Gene symbol
polA
Gene description
5' to 3' DNA polymerase and 3' to 5'/5' to 3' exonuclease
Primary source
EcoGene:EG10746
Locus tag
b3863
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
Also known as
ECK3855; JW3835; resA
Summary
Residues 324-928 constitute the Klenow fragment. [More information is available at EcoGene: EG10746]. DNA Polymerase I (Pol I) is a multifunctional enzyme that combines a DNA polymerase activity, a 5' to 3' exonuclease activity and a 3' to 5' proofreading exonuclease activity. [More information is available at EcoCyc: EG10746].
Sequence:
NC_000913.3 (4046966..4049752)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF945 family protein Neighboring gene inner membrane protein, inner membrane acyltransferase Neighboring gene ncRNA Neighboring gene cell division GTP-binding protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Base excision repair, organism-specific biosystem (from KEGG)
    Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Base excision repair, conserved biosystem (from KEGG)
    Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • DNA replication, organism-specific biosystem (from KEGG)
    DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • DNA replication, conserved biosystem (from KEGG)
    DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • Homologous recombination, organism-specific biosystem (from KEGG)
    Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Homologous recombination, conserved biosystem (from KEGG)
    Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Nucleotide excision repair, organism-specific biosystem (from KEGG)
    Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
  • Nucleotide excision repair, conserved biosystem (from KEGG)
    Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Pyrimidine metabolism, organism-specific biosystem (from KEGG)
    Pyrimidine metabolism, organism-specific biosystem
    Pyrimidine metabolism
  • Pyrimidine metabolism, conserved biosystem (from KEGG)
    Pyrimidine metabolism, conserved biosystem
    Pyrimidine metabolism
Names
5' to 3' DNA polymerase and 3' to 5'/5' to 3' exonuclease
NP_418300.1
  • DNA polymerase I, 3' --> 5' polymerase, 5' --> 3' and 3' --> 5' exonuclease

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 

    Range
    4046966..4049752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418300.1 5' to 3' DNA polymerase and 3' to 5'/5' to 3' exonuclease [Escherichia coli str. K-12 substr. MG1655]

    See proteins identical to NP_418300.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00582
    Conserved Domains (5) summary
    cd08637
    Location:548925
    DNA_pol_A_pol_I_C; Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication
    cd06139
    Location:345539
    DNA_polA_I_Ecoli_like_exo; DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases
    cd09898
    Location:173252
    H3TH_53EXO; H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs
    cd09859
    Location:9166
    PIN_53EXO; PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs
    PRK05755
    Location:6928
    PRK05755; DNA polymerase I; Provisional