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    COMP cartilage oligomeric matrix protein [ Bos taurus (cattle) ]

    Gene ID: 281088, updated on 17-Sep-2016
    Gene symbol
    COMP
    Gene description
    cartilage oligomeric matrix protein
    See related
    BGD:BT11103; Ensembl:ENSBTAG00000004630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    105 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 7 AC_000164.1 (4354383..4362113)

    Chromosome 7 - AC_000164.1Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 1 Neighboring gene UPF1, RNA helicase and ATPase Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene kelch like family member 26

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • ECM proteoglycans, organism-specific biosystem (from REACTOME)
      ECM proteoglycans, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cartilage oligomeric matrix protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166517.1NP_001159989.1  cartilage oligomeric matrix protein precursor

      Status: PROVISIONAL

      Source sequence(s)
      AAFC03073993, AAFC03073995
      Related
      ENSBTAP00000006074, ENSBTAT00000006074
      Conserved Domains (6) summary
      cd00054
      Location:179215
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:418455
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:300335
      TSP3; TSP3 repeat_long [structural motif]
      pfam02412
      Location:301335
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:545742
      TSP_C; Thrombospondin C-terminal region
      cd16077
      Location:3072
      TSP-5cc; Coiled coil region of thrombospondin-5 (TSP-5)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Genomic

    1. AC_000164.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

      Range
      4354383..4362113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Btau_5.0.1

    Genomic

    1. NC_007305.6 Alternate Btau_5.0.1

      Range
      4377315..4385133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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