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    BPTF bromodomain PHD finger transcription factor [ Homo sapiens (human) ]

    Gene ID: 2186, updated on 28-Aug-2016
    Official Symbol
    BPTFprovided by HGNC
    Official Full Name
    bromodomain PHD finger transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:3581
    See related
    Ensembl:ENSG00000171634 HPRD:03490; MIM:601819; Vega:OTTHUMG00000132254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAC1; FALZ; NURF301
    Summary
    This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17q24.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (67825517..67984378)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65821644..65980494)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 67 Neighboring gene ribosomal protein L17 pseudogene 41 Neighboring gene chromosome 17 open reading frame 58 Neighboring gene transfer RNA-Arg (CCG) 2-1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    endoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    NURF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    nucleosome-remodeling factor subunit BPTF
    Names
    bromodomain and PHD domain transcription factor
    bromodomain and PHD finger-containing transcription factor
    fetal Alz-50 clone 1 protein
    fetal Alz-50 reactive clone 1
    fetal Alzheimer antigen
    nucleosome remodeling factor, large subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004459.6NP_004450.3  nucleosome-remodeling factor subunit BPTF isoform 2

      See identical proteins and their annotated locations for NP_004450.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains two additional in-frame exons in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB032251, AC134407, AK022570, AK025776, AL833375, AY282495, BC037422
      UniProtKB/Swiss-Prot
      Q12830
      Related
      ENSP00000388405, OTTHUMP00000163084, ENST00000424123, OTTHUMT00000255333
      Conserved Domains (6) summary
      cd05509
      Location:27882888
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam09606
      Location:21632583
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27262772
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:241297
      DDT; DDT domain
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    2. NM_182641.3NP_872579.2  nucleosome-remodeling factor subunit BPTF isoform 1

      See identical proteins and their annotated locations for NP_872579.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB032251, AC134407, AK022570, AK025776, AY282495, BC037422, CV809604
      Consensus CDS
      CCDS11673.1
      UniProtKB/Swiss-Prot
      Q12830
      Related
      ENSP00000307208, OTTHUMP00000163085, ENST00000306378, OTTHUMT00000255334
      Conserved Domains (6) summary
      cd05509
      Location:28052905
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam09606
      Location:20372418
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27432789
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      pfam02791
      Location:241297
      DDT; DDT domain
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      67825517..67984378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257150.3XP_005257207.1  

      Conserved Domains (6) summary
      cd05509
      Location:30433143
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:22172598
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29813027
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    2. XM_005257154.3XP_005257211.1  

      Related
      ENSP00000315454, ENST00000321892
      Conserved Domains (6) summary
      cd05509
      Location:29853085
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:22172598
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29232969
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    3. XM_005257159.2XP_005257216.1  

      Conserved Domains (7) summary
      cd05509
      Location:29003000
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam03157
      Location:22172554
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam02791
      Location:240300
      DDT; DDT domain
      COG5034
      Location:25992829
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:28382884
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    4. XM_005257161.3XP_005257218.1  

      Conserved Domains (6) summary
      cd05509
      Location:28422942
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam03157
      Location:22172554
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27802826
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    5. XM_005257153.3XP_005257210.1  

      Conserved Domains (6) summary
      cd05509
      Location:29893089
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:21632544
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29272973
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    6. XM_005257160.2XP_005257217.1  

      Conserved Domains (7) summary
      cd05509
      Location:28462946
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam03157
      Location:21202500
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam02791
      Location:240300
      DDT; DDT domain
      COG5034
      Location:25452775
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27842830
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    7. XM_005257151.3XP_005257208.1  

      Conserved Domains (6) summary
      cd05509
      Location:30423142
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:22162597
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29803026
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    8. XM_011524520.2XP_011522822.1  

      Conserved Domains (6) summary
      cd05509
      Location:30423142
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:22162597
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29803026
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    9. XM_005257155.3XP_005257212.1  

      Conserved Domains (6) summary
      cd05509
      Location:29803080
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:21542535
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29182964
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    10. XM_005257157.3XP_005257214.1  

      Conserved Domains (6) summary
      cd05509
      Location:29793079
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:21532534
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29172963
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    11. XM_005257156.3XP_005257213.1  

      Conserved Domains (6) summary
      cd05509
      Location:29803080
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:21542535
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29182964
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    12. XM_011524521.2XP_011522823.1  

      Conserved Domains (6) summary
      cd05509
      Location:29793079
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:21532534
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29172963
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    13. XM_005257158.3XP_005257215.1  

      Conserved Domains (6) summary
      cd05509
      Location:29173017
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:20912472
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:28552901
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    14. XM_011524522.2XP_011522824.1  

      Conserved Domains (6) summary
      cd05509
      Location:29163016
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:20902471
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:28542900
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    15. XM_011524523.2XP_011522825.1  

      Conserved Domains (6) summary
      cd05509
      Location:28622962
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:20362417
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:28002846
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    16. XM_011524525.2XP_011522827.1  

      Conserved Domains (6) summary
      cd05509
      Location:28042904
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:20362417
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:27422788
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    17. XM_011524526.2XP_011522828.1  

      Conserved Domains (6) summary
      cd05509
      Location:26612761
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam03157
      Location:19932373
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:25992645
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    18. XM_005257152.2XP_005257209.1  

      Conserved Domains (6) summary
      cd05509
      Location:30433143
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam02791
      Location:240300
      DDT; DDT domain
      pfam09606
      Location:22172598
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam15612
      Location:339388
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
      cd15559
      Location:392434
      PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
      cd15560
      Location:29813027
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    19. XM_017024353.1XP_016879842.1  

    20. XM_017024354.1XP_016879843.1  

    21. XM_011524524.2XP_011522826.1  

      Conserved Domains (3) summary
      cd05509
      Location:20732173
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      pfam09606
      Location:12471628
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd15560
      Location:20112057
      PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)

    RNA

    1. XR_001752449.1 RNA Sequence

    2. XR_001752450.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      65885748..66044414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)