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    CD99 CD99 molecule [ Homo sapiens (human) ]

    Gene ID: 4267, updated on 26-Jul-2015
    Official Symbol
    CD99provided by HGNC
    Official Full Name
    CD99 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:7082
    See related
    Ensembl:ENSG00000002586; HPRD:02434; HPRD:02465; MIM:313470; MIM:450000; Vega:OTTHUMG00000021073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIC2; HBA71; MIC2X; MIC2Y; MSK5X
    Summary
    The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013]
    Orthologs
    See CD99 in Epigenomics, MapViewer
    Location:
    Xp22.32 and Yp11.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (2691187..2741309)
    107 current GRCh38.p2 (GCF_000001405.28) Y NC_000024.10 (2691187..2741309)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (2609228..2659350)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (2559228..2609350)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 102 Neighboring gene microRNA 6089 Neighboring gene CD99 molecule pseudogene 1 Neighboring gene Xg blood group Neighboring gene glycogenin 2

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 102 Neighboring gene microRNA 6089 Neighboring gene CD99 molecule pseudogene 1 Neighboring gene Xg pseudogene, Y-linked 2 Neighboring gene sex determining region Y

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    CD99 antigen
    Names
    E2 antigen
    MIC2 (monoclonal antibody 12E7)
    T-cell surface glycoprotein E2
    antigen identified by monoclonal 12E7, Y homolog
    antigen identified by monoclonal antibodies 12E7, F21 and O13
    surface antigen MIC2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009174.1 RefSeqGene

      Range
      5001..55123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001122898.1NP_001116370.1  CD99 antigen isoform b precursor

      See identical proteins and their annotated locations for NP_001116370.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC010109, DT216927
      Consensus CDS
      CCDS48071.1
      UniProtKB/Swiss-Prot
      P14209
      Conserved Domains (1) summary
      pfam12301
      Location:26160
      CD99L2; CD99 antigen like protein 2
    2. NM_001277710.1NP_001264639.1  CD99 antigen isoform c precursor

      See identical proteins and their annotated locations for NP_001264639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as type II) contains an alternate internal exon in the 3' end and uses an alternate splice junction in the penultimate exon compared to variant 1. The additional exon contains an in-frame stop codon, making the resulting isoform (c, also known as CD99sh) have a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC010109, U82164
      Consensus CDS
      CCDS75947.1
      UniProtKB/Swiss-Prot
      P14209
      Related
      ENSP00000479999, ENST00000611428
      Conserved Domains (1) summary
      pfam12301
      Location:26158
      CD99L2; CD99 antigen like protein 2
    3. NM_002414.3NP_002405.1  CD99 antigen isoform a precursor

      See identical proteins and their annotated locations for NP_002405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as type I) encodes the longest isoform (a, also known as CD99wt).
      Source sequence(s)
      BC010109
      Consensus CDS
      CCDS14119.1
      UniProtKB/Swiss-Prot
      P14209
      Related
      ENSP00000370588, OTTHUMP00000022840, ENST00000381192, OTTHUMT00000055624
      Conserved Domains (1) summary
      pfam12301
      Location:26176
      CD99L2; CD99 antigen like protein 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

      Range
      2691187..2741309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p2 Primary Assembly

      Range
      2691187..2741309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274796.2XP_005274853.1  

      See identical proteins and their annotated locations for XP_005274853.1

      Conserved Domains (1) summary
      pfam12301
      Location:26148
      CD99L2; CD99 antigen like protein 2
    2. XM_005274798.3XP_005274855.1  

      See identical proteins and their annotated locations for XP_005274855.1

      Conserved Domains (1) summary
      pfam12301
      Location:26159
      CD99L2; CD99 antigen like protein 2
    3. XM_005274794.1XP_005274851.1  

      See identical proteins and their annotated locations for XP_005274851.1

      Conserved Domains (1) summary
      pfam12301
      Location:26164
      CD99L2; CD99 antigen like protein 2
    4. XM_005274797.1XP_005274854.1  

      See identical proteins and their annotated locations for XP_005274854.1

      UniProtKB/TrEMBL
      A0A096LP69
      Conserved Domains (1) summary
      pfam12301
      Location:26175
      CD99L2; CD99 antigen like protein 2
    5. XM_005274799.2XP_005274856.1  

      See identical proteins and their annotated locations for XP_005274856.1

      UniProtKB/Swiss-Prot
      P14209
      Conserved Domains (1) summary
      pfam12301
      Location:26158
      CD99L2; CD99 antigen like protein 2
    6. XM_005274532.2XP_005274589.1  

      See identical proteins and their annotated locations for XP_005274589.1

      Conserved Domains (1) summary
      pfam12301
      Location:26148
      CD99L2; CD99 antigen like protein 2
    7. XM_005274534.3XP_005274591.1  

      See identical proteins and their annotated locations for XP_005274591.1

      Conserved Domains (1) summary
      pfam12301
      Location:26159
      CD99L2; CD99 antigen like protein 2
    8. XM_005274530.1XP_005274587.1  

      See identical proteins and their annotated locations for XP_005274587.1

      Conserved Domains (1) summary
      pfam12301
      Location:26164
      CD99L2; CD99 antigen like protein 2
    9. XM_005274533.1XP_005274590.1  

      See identical proteins and their annotated locations for XP_005274590.1

      UniProtKB/TrEMBL
      A0A096LP69
      Related
      ENSP00000485427, OTTHUMP00000277775, ENST00000624481, OTTHUMT00000478890
      Conserved Domains (1) summary
      pfam12301
      Location:26175
      CD99L2; CD99 antigen like protein 2
    10. XM_005274535.2XP_005274592.1  

      See identical proteins and their annotated locations for XP_005274592.1

      UniProtKB/Swiss-Prot
      P14209
      Conserved Domains (1) summary
      pfam12301
      Location:26158
      CD99L2; CD99 antigen like protein 2

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      2639584..2689681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)