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    FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2261, updated on 26-Jul-2015
    Official Symbol
    FGFR3provided by HGNC
    Official Full Name
    fibroblast growth factor receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:3690
    See related
    Ensembl:ENSG00000068078; HPRD:00624; MIM:134934; Vega:OTTHUMG00000121148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACH; CEK2; JTK4; CD333; HSFGFR3EX
    Summary
    This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]
    Orthologs
    See FGFR3 in Epigenomics, MapViewer
    Location:
    4p16.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (1793299..1808872)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1795039..1810599)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 129, E3 ubiquitin protein ligase Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene Wolf-Hirschhorn syndrome candidate 1 Neighboring gene small Cajal body-specific RNA 22

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Achondroplasia
    MedGen: C0001080 OMIM: 100800 GeneReviews: Achondroplasia
    Compare labs
    Camptodactyly, tall stature, and hearing loss syndrome
    MedGen: C1864852 OMIM: 610474 GeneReviews: Not available
    Compare labs
    Carcinoma of cervix
    MedGen: C0302592 OMIM: 603956 GeneReviews: Not available
    Compare labs
    Crouzon syndrome with acanthosis nigricans Compare labs
    Epidermal nevus
    MedGen: C0334082 OMIM: 162900 GeneReviews: Not available
    Compare labs
    Hypochondroplasia
    MedGen: C0410529 OMIM: 146000 GeneReviews: Hypochondroplasia
    Compare labs
    Isolated coronal synostosis Compare labs
    Levy-Hollister syndrome
    MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
    Compare labs
    Malignant tumor of testis
    MedGen: C0153594 OMIM: 273300 GeneReviews: Not available
    Compare labs
    Malignant tumor of urinary bladder
    MedGen: C0005684 OMIM: 109800 GeneReviews: Not available
    Compare labs
    Muenke syndrome Compare labs
    Thanatophoric dysplasia type 1
    MedGen: C1868678 OMIM: 187600 GeneReviews: Thanatophoric Dysplasia
    Compare labs
    Thanatophoric dysplasia, type 2
    MedGen: C1300257 OMIM: 187601 GeneReviews: Thanatophoric Dysplasia
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2011-11-09)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2011-11-09)

    ClinGen Genome Curation PagePubMed

    NHGRI GWAS Catalog

    Description
    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
    NHGRI GWA Catalog
    A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    NHGRI GWA Catalog
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    • Signaling by activated point mutants of FGFR3, organism-specific biosystem (from REACTOME)
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    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
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    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
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    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
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    • Signalling by NGF, organism-specific biosystem (from REACTOME)
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    • t(4;14) translocations of FGFR3, organism-specific biosystem (from REACTOME)
      t(4;14) translocations of FGFR3, organism-specific biosystemTranslocations which put the FGFR3 gene under the control of the strong IGH promoter have been identified in 15% of multiple myelomas (Avet-Loiseau, 1998; Chesi, 1997; Chesi, 2001). This translocati...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    fibroblast growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    alveolar secondary septum development IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis involved in innervation IEA
    Inferred from Electronic Annotation
    more info
     
    bone maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    bone morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    bone morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    central nervous system myelination IEA
    Inferred from Electronic Annotation
    more info
     
    chondrocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    chondrocyte proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    endochondral bone growth TAS
    Traceable Author Statement
    more info
    PubMed 
    endochondral ossification TAS
    Traceable Author Statement
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    epithelial cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor receptor apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    forebrain development IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
     
    inner ear receptor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    lens fiber cell development IEA
    Inferred from Electronic Annotation
    more info
     
    lens morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    morphogenesis of an epithelium IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of developmental growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of phospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of Stat1 protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat3 protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    somatic stem cell maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    substantia nigra development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    fibroblast growth factor receptor 3
    Names
    FGFR-3
    fibroblast growth factor receptor 3 variant 4
    hydroxyaryl-protein kinase
    tyrosine kinase JTK4
    NP_000133.1
    NP_001156685.1
    NP_075254.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012632.1 RefSeqGene

      Range
      5001..20561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000142.4NP_000133.1  fibroblast growth factor receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. The resulting protein (isoform 1) has the IIIc-type C-terminal half of the IgIII domain.
      Source sequence(s)
      AC016773, AW204106, BC121175, DR003490, M64347
      Consensus CDS
      CCDS3353.1
      UniProtKB/Swiss-Prot
      P22607
      UniProtKB/TrEMBL
      Q0IJ44
      Related
      ENSP00000414914, ENST00000440486
      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:472748
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:459792
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001163213.1NP_001156685.1  fibroblast growth factor receptor 3 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001156685.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as isoform IIIb, contains alternatively spliced exon 8 but lacks exon 9, compared to variant 1. The resulting protein (isoform 3) has the IIIb-type C-terminal half of the IgIII domain and is longer when it is compared to isoform 1.
      Source sequence(s)
      AB209441, AC016773, AW204106, BC121175
      Consensus CDS
      CCDS54706.1
      UniProtKB/Swiss-Prot
      P22607
      UniProtKB/TrEMBL
      Q0IJ44
      Related
      ENSP00000339824, ENST00000340107
      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:474750
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:461794
      PKc_like; Protein Kinases, catalytic domain
    3. NM_022965.3NP_075254.1  fibroblast growth factor receptor 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_075254.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exons 8, 9 and 10, compared to variant 1. The resulting protein (isoform 2) is missing the C-terminal half of the IgIII domain and the transmembrane region, compared to isoform 1. The missing transmembrane region suggests that isoform 2 is a soluble receptor.
      Source sequence(s)
      AC016773, AF245114, AW204106, BC121175, DR003490
      Consensus CDS
      CCDS3354.1
      UniProtKB/Swiss-Prot
      P22607
      UniProtKB/TrEMBL
      Q0IJ44
      Related
      ENSP00000412903, ENST00000412135
      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd04974
      Location:268357
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:260289
      IG; Immunoglobulin
      pfam07714
      Location:360636
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:347680
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      1793299..1808872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713868.1XP_006713931.1  

      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:476752
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:463797
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006713869.1XP_006713932.1  

      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:476752
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:463796
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006713870.1XP_006713933.1  

      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:475751
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:462796
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006713871.1XP_006713934.1  

      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:474750
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:461795
      PKc_like; Protein Kinases, catalytic domain
    5. XM_011513420.1XP_011511722.1  

      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:474750
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:461795
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011513422.1XP_011511724.1  

      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:473749
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:460794
      PKc_like; Protein Kinases, catalytic domain
    7. XM_006713872.1XP_006713935.1  

      See identical proteins and their annotated locations for XP_006713935.1

      UniProtKB/TrEMBL
      X5D2G8
      Related
      ENSP00000420533, OTTHUMP00000217007, ENST00000481110, OTTHUMT00000358204
      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:473749
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:460793
      PKc_like; Protein Kinases, catalytic domain
    8. XM_006713873.1XP_006713936.1  

      Conserved Domains (7) summary
      cd00096
      Location:57110
      Ig; Immunoglobulin domain
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:170235
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:472748
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:459793
      PKc_like; Protein Kinases, catalytic domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      1792977..1808551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)