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Nr2c2 nuclear receptor subfamily 2, group C, member 2 [ Mus musculus (house mouse) ]

Gene ID: 22026, updated on 26-Apr-2015
Official Symbol
Nr2c2provided by MGI
Official Full Name
nuclear receptor subfamily 2, group C, member 2provided by MGI
Primary source
MGI:MGI:1352466
See related
Ensembl:ENSMUSG00000005893; Vega:OTTMUSG00000022788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tr4; TAK1; mKIAA4145
Orthologs
See Nr2c2 in MapViewer
Location:
6; 6 D1
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (92090368..92173058)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (92041412..92123052)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930590J08 gene Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene rabenosyn, RAB effector Neighboring gene thyrotropin releasing hormone

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • KIAA4145, MGC124356, MGC124357, MGC124358

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nuclear receptor subfamily 2 group C member 2
Names
nuclear receptor subfamily 2 group C member 2
nuclear receptor subfamily 2, group H, member 2
orphan nuclear receptor TAK1
orphan nuclear receptor TR4
orphan receptor, TR4
testicular receptor 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011630.3NP_035760.1  nuclear receptor subfamily 2 group C member 2

    See identical proteins and their annotated locations for NP_035760.1

    Status: VALIDATED

    Source sequence(s)
    AC121593, AC164642, BB613881, BC103683, BQ175027
    Consensus CDS
    CCDS20372.1
    UniProtKB/Swiss-Prot
    P49117
    UniProtKB/TrEMBL
    Q3ZAS1
    Related
    ENSMUSP00000109087, OTTMUSP00000026154, ENSMUST00000113460, OTTMUST00000054739
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    92090368..92173058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505904.2XP_006505967.1  

    See identical proteins and their annotated locations for XP_006505967.1

    UniProtKB/Swiss-Prot
    P49117
    UniProtKB/TrEMBL
    Q3ZAS1
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  2. XM_006505906.2XP_006505969.1  

    See identical proteins and their annotated locations for XP_006505969.1

    UniProtKB/Swiss-Prot
    P49117
    UniProtKB/TrEMBL
    Q3ZAS1
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  3. XM_006505902.2XP_006505965.1  

    See identical proteins and their annotated locations for XP_006505965.1

    UniProtKB/TrEMBL
    G3X9W4
    Conserved Domains (2) summary
    cd06952
    Location:394615
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:145231
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  4. XM_006505903.2XP_006505966.1  

    See identical proteins and their annotated locations for XP_006505966.1

    UniProtKB/TrEMBL
    G3X9W4
    Conserved Domains (2) summary
    cd06952
    Location:394615
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:145231
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  5. XM_006505905.2XP_006505968.1  

    See identical proteins and their annotated locations for XP_006505968.1

    UniProtKB/Swiss-Prot
    P49117
    UniProtKB/TrEMBL
    Q3ZAS1
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  6. XM_006505908.2XP_006505971.1  

    Conserved Domains (2) summary
    cd06952
    Location:182403
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cl02596
    Location:119
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    93985636..94068601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)