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    Nr2c2 nuclear receptor subfamily 2, group C, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22026, updated on 10-Apr-2016
    Official Symbol
    Nr2c2provided by MGI
    Official Full Name
    nuclear receptor subfamily 2, group C, member 2provided by MGI
    Primary source
    MGI:MGI:1352466
    See related
    Ensembl:ENSMUSG00000005893 Vega:OTTMUSG00000022788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tr4; TAK1; mKIAA4145
    Orthologs
    Location:
    6; 6 D1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (92090368..92173058)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (92041412..92123052)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930590J08 gene Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene rabenosyn, RAB effector Neighboring gene thyrotropin releasing hormone

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • KIAA4145, MGC124356, MGC124357, MGC124358

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    nuclear receptor subfamily 2 group C member 2
    Names
    nuclear receptor subfamily 2, group H, member 2
    orphan nuclear receptor TAK1
    orphan nuclear receptor TR4
    orphan receptor, TR4
    testicular receptor 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011630.3NP_035760.1  nuclear receptor subfamily 2 group C member 2

      See identical proteins and their annotated locations for NP_035760.1

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642, BB613881, BC103683, BQ175027
      Consensus CDS
      CCDS20372.1
      UniProtKB/Swiss-Prot
      P49117
      UniProtKB/TrEMBL
      Q3ZAS1
      Related
      ENSMUSP00000109087, OTTMUSP00000026154, ENSMUST00000113460, OTTMUST00000054739
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

      Range
      92090368..92173058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505904.2XP_006505967.1  

      See identical proteins and their annotated locations for XP_006505967.1

      UniProtKB/Swiss-Prot
      P49117
      UniProtKB/TrEMBL
      Q3ZAS1
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    2. XM_006505906.2XP_006505969.1  

      See identical proteins and their annotated locations for XP_006505969.1

      UniProtKB/Swiss-Prot
      P49117
      UniProtKB/TrEMBL
      Q3ZAS1
      Related
      ENSMUSP00000138465, OTTMUSP00000065200, ENSMUST00000146175, OTTMUST00000054822
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    3. XM_006505902.2XP_006505965.1  

      See identical proteins and their annotated locations for XP_006505965.1

      UniProtKB/TrEMBL
      G3X9W4
      Conserved Domains (2) summary
      cd06952
      Location:394615
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:145231
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    4. XM_006505903.2XP_006505966.1  

      See identical proteins and their annotated locations for XP_006505966.1

      UniProtKB/TrEMBL
      G3X9W4
      Related
      ENSMUSP00000109090, OTTMUSP00000026177, ENSMUST00000113463, OTTMUST00000054794
      Conserved Domains (2) summary
      cd06952
      Location:394615
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:145231
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    5. XM_006505905.2XP_006505968.1  

      See identical proteins and their annotated locations for XP_006505968.1

      UniProtKB/Swiss-Prot
      P49117
      UniProtKB/TrEMBL
      Q3ZAS1
      Conserved Domains (2) summary
      cd06952
      Location:361582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
    6. XM_006505908.2XP_006505971.1  

      Conserved Domains (2) summary
      cd06952
      Location:182403
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cl02596
      Location:119
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    Alternate Mm_Celera

    Genomic

    1. AC_000028.1 Alternate Mm_Celera

      Range
      93985636..94068601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)