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SFTPD surfactant protein D [ Homo sapiens (human) ]

Gene ID: 6441, updated on 15-Sep-2014
Official Symbol
SFTPDprovided by HGNC
Official Full Name
surfactant protein Dprovided by HGNC
Primary source
HGNC:HGNC:10803
See related
Ensembl:ENSG00000133661; HPRD:01522; MIM:178635; Vega:OTTHUMG00000018590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP-D; PSP-D; SFTP4; COLEC7
See SFTPD in Epigenomics, MapViewer
Location:
10q22.2-q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (79937740..79949105, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81697496..81708861, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein geranylgeranyltransferase type I, beta subunit pseudogene 2 Neighboring gene BMS1 homolog, ribosome assembly protein (yeast) pseudogene Neighboring gene mannose-binding lectin (protein A) 1, pseudogene Neighboring gene zinc and ring finger 2 pseudogene 3 Neighboring gene uncharacterized LOC102723664 Neighboring gene C1D nuclear receptor corepressor pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SP-D enhances the binding of HIV-1 gp120 to iMDDCs and induces viral uptake and transfer of HIV from iMDDCs to CD4+ T cells PubMed
env The binding of sDC-SIGN to HIV-1 gp120 is significantly inhibited by SP-D in a dose-dependent manner, indicating an overlap with the binding site for SP-D PubMed
env Surfactant protein D (SP-D) binds to HIV-1 gp120 and inhibits HIV infectivity; the binding of SP-D to gp120 depends on glycosylation of gp120 and multimerization of SP-D PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage chemotaxis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of interleukin-2 biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phagocytosis TAS
Traceable Author Statement
more info
PubMed 
reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
regulation of cytokine production NAS
Non-traceable Author Statement
more info
PubMed 
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
lysosome TAS
Traceable Author Statement
more info
PubMed 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pulmonary surfactant-associated protein D
Names
pulmonary surfactant-associated protein D
collectin 7
collectin-7
lung surfactant protein D
pulmonary surfactant apoprotein
surfactant, pulmonary-associated protein D
surfactant-associated protein, pulmonary 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003019.4NP_003010.4  pulmonary surfactant-associated protein D precursor

    See proteins identical to NP_003010.4

    Status: VALIDATED

    Source sequence(s)
    BC022318, BI820265, BM985387
    Consensus CDS
    CCDS7362.1
    UniProtKB/Swiss-Prot
    P35247
    Related
    ENSP00000361366, OTTHUMP00000019944, ENST00000372292, OTTHUMT00000049011
    Conserved Domains (3) summary
    pfam09006
    Location:224269
    Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization
    cd03591
    Location:262375
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:130201
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    79937740..79949105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    75540246..75551613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    81980534..81991901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)