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Apc2 Adenomatous polyposis coli tumor suppressor homolog 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42871, updated on 18-Jul-2014
Official Symbol
Apc2provided by FlyBase
Official Full Name
Adenomatous polyposis coli tumor suppressor homolog 2provided by FlyBase
Primary source
FLYBASE:FBgn0026598
Locus tag
Dmel_CG6193
Gene type
protein coding
RNA name
adenomatous polyposis coli tumor suppressor homolog 2
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
APC; apc2; APC2; CG6193; d-APC2; D-APC2; dApc2; dAPC2; dAPC2/E-APC; Dm APC2; Dmel\CG6193; e-apc; E-APC; E-APC dAPC2
See Apc2 in Epigenomics, MapViewer
Location:
95E6-95E6
Exon count:
3
Annotation release Status Assembly Chr Location
Build 5.57 current Release 5 (GCF_000001215.2) 3R NT_033777.2 (19989688..19993485)

Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG6178 gene product from transcript CG6178-RA Neighboring gene Myosin 95E Neighboring gene CG6182 gene product from transcript CG6182-RA Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene CG5510 gene product from transcript CG5510-RA Neighboring gene CG13606 gene product from transcript CG13606-RD Neighboring gene CG6198 gene product from transcript CG6198-RA Neighboring gene CG5515 gene product from transcript CG5515-RC

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
chitin-based larval cuticle pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 
cytokinesis TAS
Traceable Author Statement
more info
PubMed 
establishment of mitotic spindle localization TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of microtubule cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 
head involution IGI
Inferred from Genetic Interaction
more info
PubMed 
imaginal disc pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
medulla oblongata development IGI
Inferred from Genetic Interaction
more info
PubMed 
microtubule-based process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
microtubule-based process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
oocyte localization involved in germarium-derived egg chamber formation IGI
Inferred from Genetic Interaction
more info
PubMed 
oocyte localization involved in germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process IGI
Inferred from Genetic Interaction
more info
 
positive regulation of proteolysis TAS
Traceable Author Statement
more info
PubMed 
pseudocleavage involved in syncytial blastoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
single organismal cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
syncytial nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction TAS
Traceable Author Statement
more info
PubMed 
apical cortex IDA
Inferred from Direct Assay
more info
PubMed 
apicolateral plasma membrane TAS
Traceable Author Statement
more info
PubMed 
beta-catenin destruction complex IC
Inferred by Curator
more info
 
beta-catenin destruction complex IPI
Inferred from Physical Interaction
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
microtubule associated complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
CG6193 gene product from transcript CG6193-RA
Names
Apc2-PA
CG6193-PA
adenomatous polyposis coli 2
adenomatous polyposis coli tumor suppressor homolog 2
epithelial adenomatous polyposis coli

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.2 

    Range
    19989688..19993485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058082.3NP_477430.1  adenomatous polyposis coli tumor suppressor homolog 2 [Drosophila melanogaster]

    See proteins identical to NP_477430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y1T2
    Related
    FBpp0083937, FBtr0084552
    Conserved Domains (3) summary
    pfam05972
    Location:497512
    Blast Score: 89
    APC_15aa; APC 15 residue motif
    pfam05923
    Location:736761
    Blast Score: 101
    APC_crr; APC cysteine-rich region
    cd00020
    Location:281400
    Blast Score: 206
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...