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Map3k7 mitogen-activated protein kinase kinase kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 26409, updated on 11-Sep-2014
Official Symbol
Map3k7provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 7provided by MGI
Primary source
MGI:1346877
Locus tag
RP23-447J12.1
See related
Ensembl:ENSMUSG00000028284; Vega:OTTMUSG00000004905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tak1; C87327; B430101B05
See Map3k7 in Epigenomics, MapViewer
Location:
4 A5; 4
Exon count:
17
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 4 NC_000070.6 (31964102..32023470)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102634953 Neighboring gene uncharacterized LOC102635027 Neighboring gene predicted gene 11927 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of ripoptosome assembly involved in necroptotic process IGI
Inferred from Genetic Interaction
more info
 
neural tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to stress IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase 7
Names
mitogen-activated protein kinase kinase kinase 7
TGF-beta activated kinase 1
TGF-beta-activated kinase 1
mitogen activated protein kinase kinase kinase 7
transforming growth factor beta-activated kinase 1
transforming growth factor-beta-activated kinase 1
NP_033342.1
NP_766276.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009316.1NP_033342.1  mitogen-activated protein kinase kinase kinase 7 isoform B

    See proteins identical to NP_033342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) represents the longer transcript and encodes the longer isoform (B).
    Source sequence(s)
    AK137046, AL833781, CV559615
    Consensus CDS
    CCDS51133.1
    UniProtKB/TrEMBL
    Q543B5
    UniProtKB/TrEMBL
    Q923A8
    Related
    ENSMUSP00000040307, OTTMUSP00000005099, ENSMUST00000037607, OTTMUST00000010919
    Conserved Domains (3) summary
    cd00192
    Location:40285
    Blast Score: 585
    PTKc; Catalytic domain of Protein Tyrosine Kinases
    PRK06800
    Location:516603
    Blast Score: 85
    fliH; flagellar assembly protein H; Validated
    smart00219
    Location:36284
    Blast Score: 619
    TyrKc; Tyrosine kinase, catalytic domain
  2. NM_172688.3NP_766276.1  mitogen-activated protein kinase kinase kinase 7 isoform A

    See proteins identical to NP_766276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) lacks an in-frame coding segment, compared to variant B. The resulting isoform (A) lacks an internal region, as compared to isoform B.
    Source sequence(s)
    AK137046, AL833781
    Consensus CDS
    CCDS18014.1
    UniProtKB/TrEMBL
    Q543B5
    UniProtKB/Swiss-Prot
    Q62073
    Related
    ENSMUSP00000079734, OTTMUSP00000005100, ENSMUST00000080933, OTTMUST00000010920
    Conserved Domains (3) summary
    cd00192
    Location:40285
    Blast Score: 585
    PTKc; Catalytic domain of Protein Tyrosine Kinases
    PRK06800
    Location:489576
    Blast Score: 85
    fliH; flagellar assembly protein H; Validated
    smart00219
    Location:36284
    Blast Score: 619
    TyrKc; Tyrosine kinase, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000070.6 

    Range
    31964102..32023470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537948.1XP_006538011.1  

    Conserved Domains (2) summary
    PRK06800
    Location:386473
    Blast Score: 86
    fliH; flagellar assembly protein H; Validated
    cl09925
    Location:2155
    Blast Score: 360
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_390323.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000026.1 

    Range
    31710402..31768496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)