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    Sharpin SHANK-associated RH domain interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 106025, updated on 19-Jul-2016
    Official Symbol
    Sharpinprovided by MGI
    Official Full Name
    SHANK-associated RH domain interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1913331
    See related
    Ensembl:ENSMUSG00000022552 Vega:OTTMUSG00000023724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cpdm; SIPL1; RBCKL1; AW121341; 0610041B22Rik
    Orthologs
    Location:
    15 D3; 15 35.75 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (76347040..76351115, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (76177470..76181540, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6, pseudogene 1 Neighboring gene cytochrome c-1 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III Neighboring gene predicted gene, 35339

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    chronic proliferative dermatitis
    GeneReviews: Not available
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    polyubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic nuclear changes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein linear polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein linear polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of CD40 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    LUBAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    LUBAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    sharpin
    Names
    mSIPL1
    protein kinase C-interacting protein RBCC like 1
    shank-associated RH domain-interacting protein
    shank-interacting protein-like 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025340.2NP_079616.2  sharpin

      See identical proteins and their annotated locations for NP_079616.2

      Status: VALIDATED

      Source sequence(s)
      BC016203, BI729629
      Consensus CDS
      CCDS37121.1
      UniProtKB/Swiss-Prot
      Q91WA6
      Related
      ENSMUSP00000023211, OTTMUSP00000028019, ENSMUST00000023211, OTTMUST00000057935
      Conserved Domains (4) summary
      pfam00641
      Location:345369
      zf-RanBP; Zn-finger in Ran binding protein and others
      sd00029
      Location:345364
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl00155
      Location:218297
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:18126
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      76347040..76351115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245398.1XP_011243700.1  

      Conserved Domains (4) summary
      smart00547
      Location:293314
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:293312
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl00155
      Location:166245
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    2. XM_006520263.2XP_006520326.1  

      Conserved Domains (3) summary
      cl02656
      Location:209233
      zf-RanBP; Zn-finger in Ran binding protein and others
      sd00029
      Location:209228
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl00155
      Location:82161
      UBQ; Ubiquitin-like proteins
    3. XM_011245399.1XP_011243701.1  

      Conserved Domains (1) summary
      cl17171
      Location:18126
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_383966.1 RNA Sequence

      Related
      ENSMUST00000154477