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    SIR2 NAD-dependent histone deacetylase SIR2 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851520, updated on 7-Feb-2016
    Gene symbol
    SIR2
    Gene description
    NAD-dependent histone deacetylase SIR2
    Primary source
    SGD:S000002200
    Locus tag
    YDL042C
    Gene type
    protein coding
    RNA name
    NAD-dependent histone deacetylase SIR2
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MAR1
    See SIR2 in MapViewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (376757..378445, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mtf2p Neighboring gene Prp11p Neighboring gene peptide alpha-N-acetyltransferase complex A subunit NAT1 Neighboring gene pheromone-regulated protein PRM7

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NAD-dependent histone deacetylase activity (H3-K14 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity (H4-K16 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to nucleosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin assembly or disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin silencing IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin silencing at rDNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin silencing at silent mating-type cassette IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin silencing at telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chronological cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA amplification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    RENT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear telomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    NAD-dependent histone deacetylase SIR2
    NP_010242.1
    • Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy; SIR2 has a paralog, HST1, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      376757..378445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180101.1NP_010242.1  NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_010242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06700
      Conserved Domains (2) summary
      cd01408
      Location:255517
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam04574
      Location:104261
      DUF592; Protein of unknown function (DUF592)