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Myo6 myosin VI [ Mus musculus (house mouse) ]

Gene ID: 17920, updated on 19-Sep-2014
Official Symbol
Myo6provided by MGI
Official Full Name
myosin VIprovided by MGI
Primary source
MGI:MGI:104785
See related
Ensembl:ENSMUSG00000033577; Vega:OTTMUSG00000017558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sv; Tlc; BC029719
See Myo6 in Epigenomics, MapViewer
Location:
9 E1; 9 43.98 cM
Exon count:
37
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (80164976..80311729)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase domain containing 2 pseudogene Neighboring gene SUMO/sentrin specific peptidase 6 Neighboring gene uncharacterized LOC102638853 Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene methyltransferase like 9 pseudogene Neighboring gene uncharacterized LOC102638964

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (3) 
  • Chemically induced (ENU) (5)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to electrical stimulus IMP
Inferred from Mutant Phenotype
more info
 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
protein targeting IPI
Inferred from Physical Interaction
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
PubMed 
synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
DNA-directed RNA polymerase II, holoenzyme ISO
Inferred from Sequence Orthology
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with clathrin-coated endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic membrane-bounded vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
filamentous actin ISO
Inferred from Sequence Orthology
more info
 
intracellular IPI
Inferred from Physical Interaction
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
microvillus ISO
Inferred from Sequence Orthology
more info
 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
vesicle membrane IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
unconventional myosin-VI
Names
unconventional myosin-VI
myosin-VI
tailchaser
Snell's waltzer
unconventional myosin-6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039546.2NP_001034635.2  unconventional myosin-VI

    Status: VALIDATED

    Source sequence(s)
    AC120388, AC159738, AK053882, AK135310, CF724817, CN539611
    Consensus CDS
    CCDS23368.1
    UniProtKB/TrEMBL
    E9Q3L1
    UniProtKB/TrEMBL
    Q8BK95
    Related
    ENSMUSP00000036181, OTTMUSP00000019172, ENSMUST00000035889, OTTMUST00000042663
    Conserved Domains (1) summary
    cd01382
    Location:54771
    MYSc_type_VI; Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    80164976..80311729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510839.1XP_006510902.1  

    Conserved Domains (1) summary
    cl00286
    Location:54651
    Motor_domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
  2. XM_006510835.1XP_006510898.1  

    UniProtKB/TrEMBL
    V9GX76
    Related
    ENSMUSP00000108893, OTTMUSP00000019173, ENSMUST00000113268, OTTMUST00000042664
    Conserved Domains (2) summary
    pfam03245
    Location:9821050
    Phage_lysis; Bacteriophage Rz lysis protein
    cd01382
    Location:54771
    MYSc_type_VI; Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head) ...
  3. XM_006510836.1XP_006510899.1  

    Conserved Domains (2) summary
    pfam03245
    Location:9821050
    Phage_lysis; Bacteriophage Rz lysis protein
    cd01382
    Location:54771
    MYSc_type_VI; Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head) ...
  4. XM_006510837.1XP_006510900.1  

    Conserved Domains (2) summary
    pfam03245
    Location:9821050
    Phage_lysis; Bacteriophage Rz lysis protein
    cd01382
    Location:54771
    MYSc_type_VI; Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head) ...
  5. XM_006510838.1XP_006510901.1  

    UniProtKB/TrEMBL
    E9Q175
    Related
    ENSMUSP00000108891, OTTMUSP00000019175, ENSMUST00000113266, OTTMUST00000042666
    Conserved Domains (1) summary
    cd01382
    Location:54771
    MYSc_type_VI; Myosin motor domain, type VI myosins. Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins. It has been implicated in endocytosis, secretion, and cell migration. This catalytic (head) ...

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    77304677..77455393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008662.1: Suppressed sequence

    Description
    NM_008662.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.