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    Dlg4 discs, large homolog 4 (Drosophila) [ Mus musculus (house mouse) ]

    Gene ID: 13385, updated on 24-Apr-2016
    Official Symbol
    Dlg4provided by MGI
    Official Full Name
    discs, large homolog 4 (Drosophila)provided by MGI
    Primary source
    MGI:MGI:1277959
    See related
    Ensembl:ENSMUSG00000020886 Vega:OTTMUSG00000006024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlgh4; PSD95; SAP90; PSD-95; SAP90A
    Orthologs
    Location:
    11; 11 B4
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (70018455..70045532)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69832107..69859034)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 2 Neighboring gene acyl-Coenzyme A dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene predicted gene, 32946

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    P2Y1 nucleotide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-1 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neurexin family protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuroligin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryo development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    locomotory behavior NAS
    Non-traceable Author Statement
    more info
    PubMed 
    locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of N-methyl-D-aspartate selective glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuronal synaptic plasticity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to cocaine NAS
    Non-traceable Author Statement
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle maturation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vocalization behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellar mossy fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    disks large homolog 4
    Names
    PSD-95 alpha 2b
    PSD-95 beta
    SAP-90
    discs large homolog 4
    postsynaptic density protein 95
    synapse-associated protein 90

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109752.1NP_001103222.1  disks large homolog 4 isoform 2

      See identical proteins and their annotated locations for NP_001103222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site which results in lacking of 9 nts in the CDS, as compared to variant 1. The resulting isoform 2 is shorter but has identical N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      BC014807, BQ959940, CA320223
      Consensus CDS
      CCDS48829.1
      UniProtKB/Swiss-Prot
      Q62108
      Related
      ENSMUSP00000104229, OTTMUSP00000006267, ENSMUST00000108588, OTTMUST00000013520
      Conserved Domains (6) summary
      pfam10608
      Location:1031
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:427492
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:533649
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:308386
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:530708
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:242309
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    2. NM_007864.3NP_031890.1  disks large homolog 4 isoform 1

      See identical proteins and their annotated locations for NP_031890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC014807, BI738861, BQ959940, CA320223
      Consensus CDS
      CCDS36202.1
      UniProtKB/Swiss-Prot
      Q62108
      Related
      ENSMUSP00000018700, OTTMUSP00000006269, ENSMUST00000018700, OTTMUST00000013522
      Conserved Domains (6) summary
      pfam10608
      Location:1031
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:430495
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:536652
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:311389
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:533711
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:245312
      PDZ_assoc; PDZ-associated domain of NMDA receptors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

      Range
      70018455..70045532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532144.1XP_006532207.1  

      See identical proteins and their annotated locations for XP_006532207.1

      Conserved Domains (6) summary
      pfam10608
      Location:1031
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:460525
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:566682
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:341419
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:563741
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:275342
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    2. XM_006532148.1XP_006532211.1  

      See identical proteins and their annotated locations for XP_006532211.1

      Conserved Domains (5) summary
      cd12030
      Location:408473
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:514630
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:289367
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:511689
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:223290
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    3. XM_006532150.1XP_006532213.1  

      See identical proteins and their annotated locations for XP_006532213.1

      Conserved Domains (5) summary
      cd12030
      Location:405470
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:511627
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:286364
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:508686
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:220287
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    4. XM_006532141.1XP_006532204.1  

      See identical proteins and their annotated locations for XP_006532204.1

      Conserved Domains (6) summary
      pfam10608
      Location:7090
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:519584
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:625741
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:400478
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:622800
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:334401
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    5. XM_006532142.1XP_006532205.1  

      See identical proteins and their annotated locations for XP_006532205.1

      Conserved Domains (6) summary
      pfam10608
      Location:7090
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:489554
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:595711
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:370448
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:592770
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:304371
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    6. XM_006532143.1XP_006532206.1  

      See identical proteins and their annotated locations for XP_006532206.1

      Conserved Domains (6) summary
      pfam10608
      Location:7090
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:486551
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:592708
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:367445
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:589767
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:301368
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    7. XM_006532147.2XP_006532210.1  

      See identical proteins and their annotated locations for XP_006532210.1

      Conserved Domains (5) summary
      cd12030
      Location:409474
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:515631
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:290368
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:512690
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:224291
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    8. XM_006532149.2XP_006532212.1  

      See identical proteins and their annotated locations for XP_006532212.1

      Conserved Domains (5) summary
      cd12030
      Location:406471
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:512628
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:287365
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:509687
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:221288
      PDZ_assoc; PDZ-associated domain of NMDA receptors

    RNA

    1. XR_388345.1 RNA Sequence

    Reference GRCm38.p3 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p3 NOD/MrkTac

      Range
      122940..150013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537122.1XP_006537185.1  

      See identical proteins and their annotated locations for XP_006537185.1

      Conserved Domains (6) summary
      pfam10608
      Location:1031
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:460525
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:566682
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:341419
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:563741
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:275342
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    2. XM_006537126.1XP_006537189.1  

      See identical proteins and their annotated locations for XP_006537189.1

      Conserved Domains (5) summary
      cd12030
      Location:408473
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:514630
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:289367
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:511689
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:223290
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    3. XM_006537128.1XP_006537191.1  

      See identical proteins and their annotated locations for XP_006537191.1

      Conserved Domains (5) summary
      cd12030
      Location:405470
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:511627
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:286364
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:508686
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:220287
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    4. XM_006537119.1XP_006537182.1  

      See identical proteins and their annotated locations for XP_006537182.1

      Conserved Domains (6) summary
      pfam10608
      Location:7090
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:519584
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:625741
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:400478
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:622800
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:334401
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    5. XM_006537120.1XP_006537183.1  

      See identical proteins and their annotated locations for XP_006537183.1

      Conserved Domains (6) summary
      pfam10608
      Location:7090
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:489554
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:595711
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:370448
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:592770
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:304371
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    6. XM_006537121.1XP_006537184.1  

      See identical proteins and their annotated locations for XP_006537184.1

      Conserved Domains (6) summary
      pfam10608
      Location:7090
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
      cd12030
      Location:486551
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:592708
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:367445
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:589767
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:301368
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    7. XM_006537125.2XP_006537188.1  

      See identical proteins and their annotated locations for XP_006537188.1

      Conserved Domains (5) summary
      cd12030
      Location:409474
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:515631
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:290368
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:512690
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:224291
      PDZ_assoc; PDZ-associated domain of NMDA receptors
    8. XM_006537127.2XP_006537190.1  

      See identical proteins and their annotated locations for XP_006537190.1

      Conserved Domains (5) summary
      cd12030
      Location:406471
      SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
      cd00071
      Location:512628
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00992
      Location:287365
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:509687
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:221288
      PDZ_assoc; PDZ-associated domain of NMDA receptors

    RNA

    1. XR_390225.1 RNA Sequence

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      77566529..77594216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)