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Pick1 protein interacting with C kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 18693, updated on 7-Aug-2014
Official Symbol
Pick1provided by MGI
Official Full Name
protein interacting with C kinase 1provided by MGI
Primary source
MGI:894645
See related
Ensembl:ENSMUSG00000068206; Vega:OTTMUSG00000036025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prkcabp
See Pick1 in Epigenomics, MapViewer
Location:
15; 15 E2
Exon count:
13
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (79229161..79249466)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102632536 Neighboring gene uncharacterized LOC102632460 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 8 Neighboring gene galectin-related protein-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to decreased oxygen levels ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
dendritic spine organization ISO
Inferred from Sequence Orthology
more info
 
glial cell development ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
long term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
monoamine transport ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization TAS
Traceable Author Statement
more info
PubMed 
protein kinase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
receptor clustering ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse structure and activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal postsynaptic density IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
PRKCA-binding protein
Names
PRKCA-binding protein
protein kinase C-alpha-binding protein
protein that interacts with C kinase 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045558.1NP_001039023.1  PRKCA-binding protein

    See proteins identical to NP_001039023.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI385692, AI893973, AK090155, BU698586
    Consensus CDS
    CCDS27635.1
    UniProtKB/TrEMBL
    E9PUZ5
    UniProtKB/TrEMBL
    Q8C1W2
    Related
    ENSMUSP00000018295, OTTMUSP00000051099, ENSMUST00000018295, OTTMUST00000092449
    Conserved Domains (2) summary
    cd07659
    Location:146360
    Blast Score: 1133
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    cd00992
    Location:2399
    Blast Score: 170
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_008837.3NP_032863.2  PRKCA-binding protein

    See proteins identical to NP_032863.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI385692, AI893973, AK090155, AL591921, BU698586
    Consensus CDS
    CCDS27635.1
    UniProtKB/TrEMBL
    E9PUZ5
    UniProtKB/TrEMBL
    Q8C1W2
    Related
    ENSMUSP00000128126, OTTMUSP00000051098, ENSMUST00000163571, OTTMUST00000092448
    Conserved Domains (2) summary
    cd07659
    Location:146360
    Blast Score: 1133
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    cd00992
    Location:2399
    Blast Score: 170
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    79229161..79249466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520604.1XP_006520667.1  

    See proteins identical to XP_006520667.1

    Conserved Domains (2) summary
    cd07659
    Location:166380
    Blast Score: 1131
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    cd00992
    Location:2399
    Blast Score: 171
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_006520605.1XP_006520668.1  

    Conserved Domains (2) summary
    cd07659
    Location:166348
    Blast Score: 967
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    cd00992
    Location:2399
    Blast Score: 167
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_006520603.1XP_006520666.1  

    See proteins identical to XP_006520666.1

    Conserved Domains (2) summary
    cd07659
    Location:166380
    Blast Score: 1131
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    cd00992
    Location:2399
    Blast Score: 171
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_006520607.1XP_006520670.1  

    Conserved Domains (1) summary
    cd07659
    Location:18232
    Blast Score: 1111
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  5. XM_006520606.1XP_006520669.1  

    Conserved Domains (1) summary
    cd07659
    Location:38252
    Blast Score: 1111
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    81348803..81369231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)