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TXNRD2 thioredoxin reductase 2 [ Homo sapiens (human) ]

Gene ID: 10587, updated on 7-Dec-2014
Official Symbol
TXNRD2provided by HGNC
Official Full Name
thioredoxin reductase 2provided by HGNC
Primary source
HGNC:HGNC:18155
See related
Ensembl:ENSG00000184470; HPRD:05921; HPRD:18519; MIM:606448; Vega:OTTHUMG00000149975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR; TR3; SELZ; TRXR2; TR-BETA
Summary
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
See TXNRD2 in Epigenomics, MapViewer
Location:
22q11.21
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (19875518..19941992, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19863040..19929359, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 70 Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1-like Neighboring gene chromosome 22 open reading frame 29 Neighboring gene KIAA1652 protein Neighboring gene ribosomal protein L8 pseudogene 5 Neighboring gene catechol-O-methyltransferase Neighboring gene microRNA 4761 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
NHGRI GWA Catalog
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioredoxin-disulfide reductase activity EXP
Inferred from Experiment
more info
 
thioredoxin-disulfide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to oxygen radical TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
thioredoxin reductase 2, mitochondrial
Names
thioredoxin reductase 2, mitochondrial
selenoprotein Z
thioredoxin reductase 3
thioredoxin reductase TR3
thioredoxin reductase beta
NP_001269441.1
NP_006431.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011835.1 

    Range
    4845..71320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_417

mRNA and Protein(s)

  1. NM_001282512.1NP_001269441.1  thioredoxin reductase 2, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exons in the 3' coding region and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1 and does not contain selenocysteine.
    Source sequence(s)
    AC000078, AF044212, AF106697
    Consensus CDS
    CCDS63402.1
    UniProtKB/TrEMBL
    E7EWK1
    UniProtKB/Swiss-Prot
    Q9NNW7
    Related
    ENSP00000334451, ENST00000334363
    Conserved Domains (3) summary
    pfam00070
    Location:220295
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    cl14785
    Location:124190
    FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains
    cl19134
    Location:176250
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_006440.4NP_006431.2  thioredoxin reductase 2, mitochondrial isoform 1 precursor

    See proteins identical to NP_006431.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AF044212, AF106697, R46611
    Consensus CDS
    CCDS42981.1
    UniProtKB/Swiss-Prot
    Q9NNW7
    Related
    ENSP00000383365, OTTHUMP00000195708, ENST00000400521, OTTHUMT00000314903
    Conserved Domains (5) summary
    TIGR01438
    Location:39524
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:220295
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:395508
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl14785
    Location:124190
    FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains
    cl19134
    Location:176250
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    19875518..19941992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    19862755..19929279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    3482977..3550077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145747.1: Suppressed sequence

    Description
    NM_145747.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_145748.1: Suppressed sequence

    Description
    NM_145748.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.