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Tlr5 toll-like receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 53791, updated on 7-Aug-2014
Official Symbol
Tlr5provided by MGI
Official Full Name
toll-like receptor 5provided by MGI
Primary source
MGI:1858171
See related
Ensembl:ENSMUSG00000079164
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
See Tlr5 in Epigenomics, MapViewer
Location:
1 H5; 1 86.12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (182954788..182976044)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 185 Neighboring gene sushi domain containing 4 Neighboring gene uncharacterized LOC102637150 Neighboring gene uncharacterized LOC102636766 Neighboring gene dispatched homolog 1 (Drosophila) Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 5 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
toll-like receptor 5
Names
toll-like receptor 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016928.2NP_058624.2  toll-like receptor 5

    Status: PROVISIONAL

    Source sequence(s)
    AF186107, AI118722, AK036842, BC125247
    Consensus CDS
    CCDS35815.1
    UniProtKB/TrEMBL
    E9QL10
    UniProtKB/TrEMBL
    Q05AH3
    UniProtKB/TrEMBL
    Q8CB40
    UniProtKB/Swiss-Prot
    Q9JLF7
    Related
    ENSMUSP00000106625, ENSMUST00000110997
    Conserved Domains (3) summary
    cd00116
    Location:353595
    Blast Score: 126
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:710847
    Blast Score: 270
    TIR; TIR domain
    pfam13855
    Location:517575
    Blast Score: 135
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    182954788..182976044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    189998902..190020262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)