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    Ctgf connective tissue growth factor [ Mus musculus (house mouse) ]

    Gene ID: 14219, updated on 27-Jun-2015
    Official Symbol
    Ctgfprovided by MGI
    Official Full Name
    connective tissue growth factorprovided by MGI
    Primary source
    MGI:MGI:95537
    See related
    Ensembl:ENSMUSG00000019997; Vega:OTTMUSG00000019709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccn2; Hcs24; Fisp12; fisp-12
    Orthologs
    See Ctgf in Epigenomics, MapViewer
    Location:
    10 11.84 cM; 10 A3-B1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (24595442..24598683)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (24315248..24318489)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102638890 Neighboring gene predicted gene, 40615 Neighboring gene predicted gene, 36089 Neighboring gene predicted gene 6893 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage condensation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    connective tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosolic calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix constituent secretion ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    connective tissue growth factor
    Names
    connective tissue growth factor
    CCN family member 2
    Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
    fibroblast inducible secreated protein
    fibroblast inducible secreted protein
    hypertrophic chondrocyte-specific gene product 24
    hypertrophic chondrocyte-specific protein 24

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010217.2NP_034347.2  connective tissue growth factor precursor

      See identical proteins and their annotated locations for NP_034347.2

      Status: VALIDATED

      Source sequence(s)
      BQ031485, BQ892143, BQ917383, CB317714, CJ055589, CJ159336
      Consensus CDS
      CCDS23751.1
      UniProtKB/Swiss-Prot
      P29268
      Related
      ENSMUSP00000020171, OTTMUSP00000021306, ENSMUST00000020171, OTTMUST00000047191
      Conserved Domains (4) summary
      smart00214
      Location:102161
      VWC; von Willebrand factor (vWF) type C domain
      cl00070
      Location:252344
      GHB_like; Glycoprotein hormone beta chain homologues
      pfam00090
      Location:201241
      TSP_1; Thrombospondin type 1 domain
      pfam00219
      Location:4081
      IGFBP; Insulin-like growth factor binding protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

      Range
      24595442..24598683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      25537033..25540272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)