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Gata4 GATA binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 14463, updated on 19-Jul-2014
Official Symbol
Gata4provided by MGI
Official Full Name
GATA binding protein 4provided by MGI
Primary source
MGI:95664
See related
Ensembl:ENSMUSG00000021944; Vega:OTTMUSG00000032593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gata-4
See Gata4 in Epigenomics, MapViewer
Location:
14 D1; 14 33.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (63198915..63245266, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cathepsin B Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene nei like 2 (E. coli) Neighboring gene uncharacterized LOC102639980 Neighboring gene B lymphoid kinase Neighboring gene predicted gene, 21430

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
 
co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding RNA polymerase II transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Sertoli cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
atrial septum primum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrial septum secundum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
atrioventricular canal development IGI
Inferred from Genetic Interaction
more info
 
atrioventricular valve formation IGI
Inferred from Genetic Interaction
more info
 
atrioventricular valve morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
atrioventricular valve morphogenesis TAS
Traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle cell differentiation NAS
Non-traceable Author Statement
more info
 
cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
 
cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
 
cardiac right ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac septum development IGI
Inferred from Genetic Interaction
more info
 
cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
cell-cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to follicle-stimulating hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to gonadotropin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
diaphragm morphogenesis TAS
Traceable Author Statement
more info
PubMed 
embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic heart tube anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion development IGI
Inferred from Genetic Interaction
more info
PubMed 
endocardial cushion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
endoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intestinal epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
lung lobe formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung morphogenesis TAS
Traceable Author Statement
more info
PubMed 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
mitral valve formation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
 
signal transduction involved in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
skeletal muscle cell differentiation NAS
Non-traceable Author Statement
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
tricuspid valve formation TAS
Traceable Author Statement
more info
PubMed 
tube morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
 
ventricular cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
transcription factor GATA-4
Names
transcription factor GATA-4
GATA-binding factor 4
GATA-binding protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008092.3NP_032118.2  transcription factor GATA-4

    See proteins identical to NP_032118.2

    Status: VALIDATED

    Source sequence(s)
    AC090962, AK134639, AW558892
    Consensus CDS
    CCDS49519.1
    UniProtKB/Swiss-Prot
    Q08369
    UniProtKB/TrEMBL
    Q3UYJ1
    Related
    ENSMUSP00000113891, OTTMUSP00000043283, ENSMUST00000118022, OTTMUST00000081053
    Conserved Domains (2) summary
    cd00202
    Location:269320
    Blast Score: 213
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1207
    Blast Score: 309
    GATA-N; GATA-type transcription activator, N-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    63198915..63245266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518556.1XP_006518619.1  

    UniProtKB/TrEMBL
    E9PXW9
    Related
    ENSMUSP00000066927, OTTMUSP00000043285, ENSMUST00000067417, OTTMUST00000081055
    Conserved Domains (2) summary
    cd00202
    Location:270321
    Blast Score: 213
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    pfam05349
    Location:1204
    Blast Score: 300
    GATA-N; GATA-type transcription activator, N-terminal

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    60962648..61008982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)