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AQP5 aquaporin 5 [ Homo sapiens (human) ]

Gene ID: 362, updated on 4-May-2015
Official Symbol
AQP5provided by HGNC
Official Full Name
aquaporin 5provided by HGNC
Primary source
HGNC:HGNC:638
See related
HPRD:02706; MIM:600442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPKB; AQP-5
Summary
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
Orthologs
See AQP5 in MapViewer
Location:
12q13
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (49961496..49965682)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50355279..50359465)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369763 Neighboring gene uncharacterized LOC101927318 Neighboring gene aquaporin 2 (collecting duct) Neighboring gene uncharacterized LOC105369764 Neighboring gene uncharacterized LOC102723963 Neighboring gene aquaporin 6, kidney specific Neighboring gene Rac GTPase activating protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycerol channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
water channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
carbon dioxide transport IDA
Inferred from Direct Assay
more info
PubMed 
cellular water homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
excretion TAS
Traceable Author Statement
more info
PubMed 
glycerol transport IBA
Inferred from Biological aspect of Ancestor
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
odontogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
pancreatic juice secretion IEP
Inferred from Expression Pattern
more info
PubMed 
saliva secretion IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
water transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
microvillus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
aquaporin-5
Names
aquaporin-5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033883.1 RefSeqGene

    Range
    5001..9187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001651.3NP_001642.1  aquaporin-5

    See identical proteins and their annotated locations for NP_001642.1

    Status: REVIEWED

    Source sequence(s)
    AC025154, BC032946, BP272197, BX095029
    Consensus CDS
    CCDS8793.1
    UniProtKB/Swiss-Prot
    P55064
    Conserved Domains (1) summary
    cd00333
    Location:12224
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    49961496..49965682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268838.2XP_005268895.1  

    See identical proteins and their annotated locations for XP_005268895.1

    Conserved Domains (1) summary
    cd00333
    Location:12204
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    50321440..50325624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)