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Crtc2 CREB regulated transcription coactivator 2 [ Mus musculus (house mouse) ]

Gene ID: 74343, updated on 19-Jul-2014
Official Symbol
Crtc2provided by MGI
Official Full Name
CREB regulated transcription coactivator 2provided by MGI
Primary source
MGI:1921593
See related
Ensembl:ENSMUSG00000027936; Vega:OTTMUSG00000021260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Torc2; mTORC2; 4632407F12Rik
See Crtc2 in Epigenomics, MapViewer
Location:
3; 3 F2
Exon count :
15
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 3 NC_000069.6 (90254168..90264125)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene solute carrier family 39 (zinc transporter), member 1 Neighboring gene DENN/MADD domain containing 4B Neighboring gene microRNA mir-7012 Neighboring gene GATA zinc finger domain containing 2B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cAMP response element binding protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K9 acetylation IGI
Inferred from Genetic Interaction
more info
 
positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
 
protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
CREB-regulated transcription coactivator 2
Names
CREB-regulated transcription coactivator 2
TORC-2
transducer of CREB protein 2
transducer of regulated cAMP response element-binding protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028881.2NP_083157.1  CREB-regulated transcription coactivator 2

    See proteins identical to NP_083157.1

    Status: VALIDATED

    Source sequence(s)
    AA276938, AA611164, AC119825, BU612513, BY085181, BY230198, CO040040, CV783724
    Consensus CDS
    CCDS38501.1
    UniProtKB/Swiss-Prot
    Q3U182
    Related
    ENSMUSP00000029545, OTTMUSP00000023505, ENSMUST00000029545, OTTMUST00000050376
    Conserved Domains (3) summary
    pfam12885
    Location:168317
    Blast Score: 389
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12884
    Location:1872
    Blast Score: 237
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12886
    Location:614691
    Blast Score: 284
    TORC_C; Transducer of regulated CREB activity, C terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000069.6 

    Range
    90254168..90264125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502153.1XP_006502216.1  

    Conserved Domains (3) summary
    pfam12885
    Location:168317
    Blast Score: 394
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12884
    Location:1872
    Blast Score: 238
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12886
    Location:526603
    Blast Score: 282
    TORC_C; Transducer of regulated CREB activity, C terminus
  2. XM_006502152.1XP_006502215.1  

    Conserved Domains (3) summary
    pfam12885
    Location:145294
    Blast Score: 387
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12884
    Location:1872
    Blast Score: 237
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12886
    Location:591668
    Blast Score: 284
    TORC_C; Transducer of regulated CREB activity, C terminus
  3. XM_006502155.1XP_006502218.1  

    Conserved Domains (2) summary
    pfam12885
    Location:168317
    Blast Score: 421
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12884
    Location:1872
    Blast Score: 241
    TORC_N; Transducer of regulated CREB activity, N terminus
  4. XM_006502154.1XP_006502217.1  

    See proteins identical to XP_006502217.1

    UniProtKB/TrEMBL
    Q8R1U3
    Conserved Domains (2) summary
    pfam12885
    Location:1138
    Blast Score: 317
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:435512
    Blast Score: 276
    TORC_C; Transducer of regulated CREB activity, C terminus

RNA

  1. XR_375593.1 RNA Sequence

  2. XR_375594.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000025.1 

    Range
    90292041..90301887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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