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Pecam1 platelet/endothelial cell adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 18613, updated on 17-May-2015
Official Symbol
Pecam1provided by MGI
Official Full Name
platelet/endothelial cell adhesion molecule 1provided by MGI
Primary source
MGI:MGI:97537
See related
Ensembl:ENSMUSG00000020717; Vega:OTTMUSG00000003418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd31; Pecam; C85791; PECAM-1
Orthologs
See Pecam1 in MapViewer
Location:
11; 11 E1
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (106654217..106750623, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106515532..106576595, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene predicted gene, 36220 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene testis expressed gene 2 Neighboring gene mast cell immunoglobulin like receptor 1 Neighboring gene polymerase (DNA directed), gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Markers

Homology

Clone Names

  • MGC102160

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
diapedesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat5 protein IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
smooth muscle contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
platelet endothelial cell adhesion molecule
Names
platelet endothelial cell adhesion molecule

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032378.2NP_001027550.1  platelet endothelial cell adhesion molecule isoform 2 precursor

    See identical proteins and their annotated locations for NP_001027550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 3' coding exon but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AK169431, BC085502, BE692027, BY781761
    Consensus CDS
    CCDS25558.1
    UniProtKB/Swiss-Prot
    Q08481
    Related
    ENSMUSP00000099358, OTTMUSP00000003452, ENSMUST00000103069, OTTMUST00000007191
    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  2. NM_001305157.1NP_001292086.1  platelet endothelial cell adhesion molecule isoform 3 precursor

    See identical proteins and their annotated locations for NP_001292086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' coding exon, which results in a frameshift, compared to variant 1. It encodes isoform 3 which has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK084527, AK169431, BE692027, BY781761
    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  3. NM_001305158.1NP_001292087.1  platelet endothelial cell adhesion molecule isoform 4 precursor

    See identical proteins and their annotated locations for NP_001292087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame 5' coding exon, and contains an alternate 3' coding exon which results in a frameshift, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK037551, AK084527, AK169431, BE692027, BY781761
    Conserved Domains (4) summary
    smart00408
    Location:227276
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:215292
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  4. NM_008816.3NP_032842.2  platelet endothelial cell adhesion molecule isoform 1 precursor

    See identical proteins and their annotated locations for NP_032842.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK084527, BE692027, BY781761
    Consensus CDS
    CCDS25559.1
    UniProtKB/Swiss-Prot
    Q08481
    Related
    ENSMUSP00000079664, OTTMUSP00000003454, ENSMUST00000080853, OTTMUST00000007193
    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    106654217..106750623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248792.1XP_011247094.1  

    See identical proteins and their annotated locations for XP_011247094.1

    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  2. XM_006532476.1XP_006532539.1  

    Related
    ENSMUSP00000138959, OTTMUSP00000065669, ENSMUST00000183610, OTTMUST00000117407
    Conserved Domains (4) summary
    smart00408
    Location:227276
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:215292
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  3. XM_006532474.1XP_006532537.1  

    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  4. XM_006532473.1XP_006532536.1  

    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  5. XM_011248793.1XP_011247095.1  

    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  6. XM_006532472.1XP_006532535.1  

    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain
  7. XM_006532470.1XP_006532533.1  

    Related
    ENSMUSP00000102408, OTTMUSP00000003455, ENSMUST00000106796, OTTMUST00000007194
    Conserved Domains (4) summary
    smart00408
    Location:328377
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:33117
    IG_like; Immunoglobulin like
    pfam13895
    Location:316393
    Ig_2; Immunoglobulin domain
    cl11960
    Location:33107
    Ig; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    118385876..118446185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)