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Mtor mechanistic target of rapamycin (serine/threonine kinase) [ Mus musculus (house mouse) ]

Gene ID: 56717, updated on 30-Mar-2015
Official Symbol
Mtorprovided by MGI
Official Full Name
mechanistic target of rapamycin (serine/threonine kinase)provided by MGI
Primary source
MGI:MGI:1928394
See related
Ensembl:ENSMUSG00000028991; Vega:OTTMUSG00000010950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; AI327068; 2610315D21Rik
Orthologs
See Mtor in MapViewer
Location:
4 78.76 cM; 4 E1
Exon count:
58
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (148448582..148557685)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (147822691..147931794)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene patched domain containing 2 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene angiopoietin-like 7 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene exosome component 10 Neighboring gene spermidine synthase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
flat-top
GeneReviews: Not available

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC118056

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase III type 1 promoter DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase III type 2 promoter DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase III type 3 promoter DNA binding ISO
Inferred from Sequence Orthology
more info
 
TFIIIC-class transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
TOR signaling ISO
Inferred from Sequence Orthology
more info
 
cell growth ISO
Inferred from Sequence Orthology
more info
 
cell projection organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell projection organization ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
germ cell development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NFAT protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell size IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myotube differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase III promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of carbohydrate utilization ISO
Inferred from Sequence Orthology
more info
 
regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of response to food ISO
Inferred from Sequence Orthology
more info
 
response to amino acid IDA
Inferred from Direct Assay
more info
PubMed 
response to amino acid ISO
Inferred from Sequence Orthology
more info
 
response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
response to stress ISO
Inferred from Sequence Orthology
more info
 
ruffle organization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
TORC1 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
TORC2 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with dendrite ISO
Inferred from Sequence Orthology
more info
 
endomembrane system ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
macromolecular complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
serine/threonine-protein kinase mTOR
Names
serine/threonine-protein kinase mTOR
FK506 binding protein 12-rapamycin associated protein 1
FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP-rapamycin associated protein (FRAP)
FKBP-rapamycin-associated protein FRAP
FKBP12-rapamycin complex-associated protein
angiopoietin-like factor CDT6
mammalian target of rapamycin
rapamycin target protein 1
NP_064393.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020009.2NP_064393.2  serine/threonine-protein kinase mTOR

    See proteins identical to NP_064393.2

    Status: VALIDATED

    Source sequence(s)
    BC112904, CJ130100
    Consensus CDS
    CCDS18937.1
    UniProtKB/Swiss-Prot
    Q9JLN9
    Related
    ENSMUSP00000099510, OTTMUSP00000011776, ENSMUST00000103221, OTTMUST00000025684
    Conserved Domains (6) summary
    COG5032
    Location:3632549
    TEL1; Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication, recombination, and repair / Intracellular ...
    pfam02260
    Location:25192549
    FATC; FATC domain
    pfam08771
    Location:20152114
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:8541024
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:748805
    HEAT_EZ; HEAT-like repeat
    cd05169
    Location:21532431
    PIKKc_TOR; Catalytic domain of Target of Rapamycin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    148448582..148557685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539077.1XP_006539140.1  

    Conserved Domains (6) summary
    pfam02259
    Location:8011188
    FAT; FAT domain
    pfam02260
    Location:17991829
    FATC; FATC domain
    pfam08771
    Location:12951394
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:134304
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:2885
    HEAT_EZ; HEAT-like repeat
    cd05169
    Location:14331711
    PIKKc_TOR; Catalytic domain of Target of Rapamycin

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_166299.2 Reference GRCm38.p3 NOD/MrkTac

    Range
    1861191..1971030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    150709332..150819308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)