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MAPT microtubule-associated protein tau [ Homo sapiens (human) ]

Gene ID: 4137, updated on 15-Sep-2014
Official Symbol
MAPTprovided by HGNC
Official Full Name
microtubule-associated protein tauprovided by HGNC
Primary source
HGNC:HGNC:6893
See related
Ensembl:ENSG00000186868; HPRD:01142; MIM:157140; Vega:OTTHUMG00000168833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
Summary
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
See MAPT in Epigenomics, MapViewer
Location:
17q21.1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (45894336..46028334)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43971702..44105700)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRHR1 intronic transcript 1 (non-protein coding) Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene MAPT antisense RNA 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene MAPT intronic transcript 1 (non-protein coding) Neighboring gene uncharacterized LOC102724391 Neighboring gene saitohin Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene KANSL1 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-05-08)

ISCA Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-05-08)

ISCA Genome Curation Page

NHGRI GWAS Catalog

Description
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
NHGRI GWA Catalog
Common variants at 12q15 and 12q24 are associated with infant head circumference.
NHGRI GWA Catalog
Common variants at 6q22 and 17q21 are associated with intracranial volume.
NHGRI GWA Catalog
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.
NHGRI GWA Catalog
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
NHGRI GWA Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
NHGRI GWA Catalog
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
NHGRI GWA Catalog
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
NHGRI GWA Catalog
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
NHGRI GWA Catalog
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of microglia cells with HIV-1 Tat shows TAU5 and synapsin-1 positive inclusions in cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
    Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
    BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
    Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemCaspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and ...
  • IL-2 Signaling pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
    LPA receptor mediated events, organism-specific biosystem
    LPA receptor mediated events
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Reelin signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Reelin signaling pathway, organism-specific biosystem
    Reelin signaling pathway
  • Regulation of Microtubule Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Microtubule Cytoskeleton, organism-specific biosystem
    Regulation of Microtubule Cytoskeleton
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31424, MGC138549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipoprotein particle binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
apoptotic process TAS
Traceable Author Statement
more info
 
axon cargo transport IEA
Inferred from Electronic Annotation
more info
 
axon extension IEA
Inferred from Electronic Annotation
more info
 
cellular component disassembly involved in execution phase of apoptosis TAS
Traceable Author Statement
more info
 
generation of neurons NAS
Non-traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intracellular transport IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of microtubule polymerization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axoneme IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 
nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
tubulin complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
microtubule-associated protein tau
Names
microtubule-associated protein tau
PHF-tau
paired helical filament-tau
neurofibrillary tangle protein
microtubule-associated protein tau, isoform 4
protein phosphatase 1, regulatory subunit 103
G protein beta1/gamma2 subunit-interacting factor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007398.1 

    Range
    4919..138924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001123066.3NP_001116538.2  microtubule-associated protein tau isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (6).
    Source sequence(s)
    AW295014, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS45715.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000340820, ENST00000344290
    Conserved Domains (1) summary
    pfam00418
    Location:610640
    Blast Score: 159
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. NM_001123067.3NP_001116539.1  microtubule-associated protein tau isoform 5

    See proteins identical to NP_001116539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (5) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    BC114948, CR936218, DN996935
    Consensus CDS
    CCDS45716.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000340438, ENST00000340799
    Conserved Domains (1) summary
    pfam00418
    Location:246276
    Blast Score: 152
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. NM_001203251.1NP_001190180.1  microtubule-associated protein tau isoform 7

    See proteins identical to NP_001190180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (7) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    AK095802, CR936218, DN996935
    UniProtKB/TrEMBL
    A0A024RA19
    UniProtKB/TrEMBL
    B3KTM0
    Conserved Domains (1) summary
    pfam00418
    Location:246276
    Blast Score: 142
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. NM_001203252.1NP_001190181.1  microtubule-associated protein tau isoform 8

    See proteins identical to NP_001190181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (8) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
    Source sequence(s)
    AK095802, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS56033.1
    UniProtKB/TrEMBL
    B3KTM0
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000443028, ENST00000535772
    Conserved Domains (1) summary
    pfam00418
    Location:275305
    Blast Score: 144
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. NM_005910.5NP_005901.2  microtubule-associated protein tau isoform 2

    See proteins identical to NP_005901.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (2) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
    Source sequence(s)
    BN000503, CR936218, DN996935, X14474
    Consensus CDS
    CCDS11499.1
    UniProtKB/TrEMBL
    A0A024RA17
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000303214, ENST00000351559
    Conserved Domains (1) summary
    pfam00418
    Location:275305
    Blast Score: 153
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. NM_016834.4NP_058518.1  microtubule-associated protein tau isoform 3

    See proteins identical to NP_058518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks five internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (3) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    BC114948, CR936218, DN996935
    Consensus CDS
    CCDS11500.1
    UniProtKB/TrEMBL
    A0A024R9Y0
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000408975, OTTHUMP00000239569, ENST00000446361, OTTHUMT00000401263
    Conserved Domains (1) summary
    pfam00418
    Location:217247
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. NM_016835.4NP_058519.3  microtubule-associated protein tau isoform 1

    See proteins identical to NP_058519.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks one internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (1) has identical N- and C-termini but lacks one segment, as compared to isoform 6.
    Source sequence(s)
    AW295014, BC114948, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS11501.1
    UniProtKB/TrEMBL
    A0A024R9Y1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000262410, ENST00000262410
    Conserved Domains (1) summary
    pfam00418
    Location:592622
    Blast Score: 159
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. NM_016841.4NP_058525.1  microtubule-associated protein tau isoform 4

    See proteins identical to NP_058525.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks six internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (4) has identical N- and C-termini but lacks five segments, as compared to isoform 6.
    Source sequence(s)
    BC000558, CR936218, DN996935
    Consensus CDS
    CCDS11502.1
    UniProtKB/Swiss-Prot
    P10636
    Conserved Domains (1) summary
    pfam00418
    Location:217247
    Blast Score: 141
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 

    Range
    760287..893837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725275.1XP_006725338.1  

    See proteins identical to XP_006725338.1

    UniProtKB/Swiss-Prot
    P10636
    Conserved Domains (1) summary
    pfam00418
    Location:217247
    Blast Score: 141
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. XM_006725274.1XP_006725337.1  

    See proteins identical to XP_006725337.1

    UniProtKB/TrEMBL
    A0A024R9Y0
    UniProtKB/Swiss-Prot
    P10636
    Conserved Domains (1) summary
    pfam00418
    Location:217247
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. XM_006725272.1XP_006725335.1  

    See proteins identical to XP_006725335.1

    Conserved Domains (1) summary
    pfam00418
    Location:283313
    Blast Score: 151
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. XM_006725268.1XP_006725331.1  

    Conserved Domains (1) summary
    pfam00418
    Location:638668
    Blast Score: 160
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. XM_006725273.1XP_006725336.1  

    Conserved Domains (1) summary
    pfam00418
    Location:224254
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. XM_006725271.1XP_006725334.1  

    Conserved Domains (1) summary
    pfam00418
    Location:290320
    Blast Score: 151
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. XM_006725270.1XP_006725333.1  

    See proteins identical to XP_006725333.1

    Conserved Domains (1) summary
    pfam00418
    Location:312342
    Blast Score: 152
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. XM_006725266.1XP_006725329.1  

    Conserved Domains (1) summary
    pfam00418
    Location:667697
    Blast Score: 161
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  9. XM_005275647.1XP_005275704.1  

    Conserved Domains (1) summary
    pfam00418
    Location:341371
    Blast Score: 154
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  10. XM_006725269.1XP_006725332.1  

    Conserved Domains (1) summary
    pfam00418
    Location:630660
    Blast Score: 161
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  11. XM_006725267.1XP_006725330.1  

    Conserved Domains (1) summary
    pfam00418
    Location:696726
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  12. XM_006725265.1XP_006725328.1  

    Conserved Domains (1) summary
    pfam00418
    Location:696726
    Blast Score: 161
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  13. XM_005275648.2XP_005275705.1  

    Conserved Domains (1) summary
    pfam00418
    Location:224254
    Blast Score: 146
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

Reference GRCh38 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 

    Range
    596467..730446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725624.1XP_006725687.1  

    Conserved Domains (1) summary
    pfam00418
    Location:283313
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. XM_006725616.1XP_006725679.1  

    Conserved Domains (1) summary
    pfam00418
    Location:696726
    Blast Score: 160
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. XM_006725618.1XP_006725681.1  

    Conserved Domains (1) summary
    pfam00418
    Location:696726
    Blast Score: 149
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. XM_006725620.1XP_006725683.1  

    Conserved Domains (1) summary
    pfam00418
    Location:630660
    Blast Score: 161
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. XM_006725621.1XP_006725684.1  

    Conserved Domains (1) summary
    pfam00418
    Location:630660
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. XM_006725617.1XP_006725680.1  

    Conserved Domains (1) summary
    pfam00418
    Location:667697
    Blast Score: 160
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. XM_006725622.1XP_006725685.1  

    Conserved Domains (1) summary
    pfam00418
    Location:341371
    Blast Score: 153
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. XM_006725623.1XP_006725686.1  

    Conserved Domains (1) summary
    pfam00418
    Location:312342
    Blast Score: 152
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  9. XM_006725619.1XP_006725682.1  

    Conserved Domains (1) summary
    pfam00418
    Location:638668
    Blast Score: 159
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  10. XM_005257372.2XP_005257429.2  

    Conserved Domains (1) summary
    pfam00418
    Location:224254
    Blast Score: 146
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  11. XM_006725625.1XP_006725688.1  

    Conserved Domains (1) summary
    pfam00418
    Location:158188
    Blast Score: 145
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    45894336..46028334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257371.2XP_005257428.1  

    Conserved Domains (1) summary
    pfam00418
    Location:283313
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. XM_005257362.2XP_005257419.1  

    Conserved Domains (1) summary
    pfam00418
    Location:696726
    Blast Score: 161
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. XM_005257365.2XP_005257422.1  

    Conserved Domains (1) summary
    pfam00418
    Location:696726
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. XM_005257367.2XP_005257424.1  

    Conserved Domains (1) summary
    pfam00418
    Location:630660
    Blast Score: 161
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. XM_005257368.2XP_005257425.1  

    Conserved Domains (1) summary
    pfam00418
    Location:630660
    Blast Score: 150
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. XM_005257364.2XP_005257421.1  

    Conserved Domains (1) summary
    pfam00418
    Location:667697
    Blast Score: 160
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. XM_005257369.2XP_005257426.1  

    Conserved Domains (1) summary
    pfam00418
    Location:341371
    Blast Score: 154
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. XM_005257370.2XP_005257427.1  

    Conserved Domains (1) summary
    pfam00418
    Location:312342
    Blast Score: 152
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  9. XM_005257366.2XP_005257423.1  

    Conserved Domains (1) summary
    pfam00418
    Location:638668
    Blast Score: 160
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    39635406..39768427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    44218591..44352524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)