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    Ahr aryl-hydrocarbon receptor [ Mus musculus (house mouse) ]

    Gene ID: 11622, updated on 30-Aug-2015
    Official Symbol
    Ahrprovided by MGI
    Official Full Name
    aryl-hydrocarbon receptorprovided by MGI
    Primary source
    MGI:MGI:105043
    See related
    Ensembl:ENSMUSG00000019256; Vega:OTTMUSG00000036999
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ah; In; Ahh; Ahre; bHLHe76
    Orthologs
    Location:
    12 A3; 12 15.78 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (35497979..35534989, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (36182651..36219661, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene sorting nexin 13 Neighboring gene microRNA 680-3 Neighboring gene RIKEN cDNA 9130015A21 gene Neighboring gene predicted gene, 40388

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    aryl hydrocarbon receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enhancer binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    B-1 B cell homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circumferential growth involved in left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    common bile duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerulus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    kidney morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of necrotic cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    patterning of blood vessels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of blood vessel size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart growth TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    venous blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    aryl hydrocarbon receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosolic aryl hydrocarbon receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear aryl hydrocarbon receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    aryl hydrocarbon receptor
    Names
    ah receptor
    dioxin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013464.4NP_038492.1  aryl hydrocarbon receptor

      See identical proteins and their annotated locations for NP_038492.1

      Status: PROVISIONAL

      Source sequence(s)
      AK153678
      Consensus CDS
      CCDS36434.1
      UniProtKB/Swiss-Prot
      P30561
      UniProtKB/TrEMBL
      Q3U5D9
      Related
      ENSMUSP00000112137, OTTMUSP00000053052, ENSMUST00000116436, OTTMUST00000095140
      Conserved Domains (4) summary
      cd00083
      Location:3677
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:120177
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:111177
      PAS; PAS fold
      pfam08447
      Location:291376
      PAS_3; PAS fold

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

      Range
      35497979..35534989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000034.1 Alternate Mm_Celera

      Range
      36948584..36984257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)