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Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 14128, updated on 8-Dec-2014
Official Symbol
Fcer2aprovided by MGI
Official Full Name
Fc receptor, IgE, low affinity II, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:95497
See related
Ensembl:ENSMUSG00000005540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD23; Fce2; Fcer2; Ly-42
See Fcer2a in Epigenomics, MapViewer
Location:
8 A1; 8 1.92 cM
Exon count:
14
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 8 NC_000074.6 (3681737..3694174, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene Foxo1 corepressor Neighboring gene trafficking protein particle complex 5 Neighboring gene predicted gene 16553 Neighboring gene C-type lectin domain family 4, member g Neighboring gene CD209a antigen

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
IgE binding IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
low affinity immunoglobulin epsilon Fc receptor
Names
low affinity immunoglobulin epsilon Fc receptor
FC epsilon RII
fc-epsilon-RII
lymphocyte IgE receptor
low-affinity IgE receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253737.1NP_001240666.1  low affinity immunoglobulin epsilon Fc receptor isoform B

    See proteins identical to NP_001240666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform B) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/Swiss-Prot
    P20693
    Conserved Domains (2) summary
    cd03590
    Location:185305
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl00143
    Location:61138
    Syntaxin; Syntaxin
  2. NM_001253739.1NP_001240668.1  low affinity immunoglobulin epsilon Fc receptor isoform C

    See proteins identical to NP_001240668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/Swiss-Prot
    P20693
    Conserved Domains (2) summary
    cd03590
    Location:185305
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl00143
    Location:61138
    Syntaxin; Syntaxin
  3. NM_001253743.1NP_001240672.1  low affinity immunoglobulin epsilon Fc receptor isoform A precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform D) is shorter when it is compared to isoform A.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/Swiss-Prot
    P20693
    Conserved Domains (2) summary
    cd03590
    Location:159279
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl00143
    Location:35112
    Syntaxin; Syntaxin
  4. NM_001253745.1NP_001240674.1  low affinity immunoglobulin epsilon Fc receptor isoform E

    See proteins identical to NP_001240674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform E) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform E has also been called Fc epsilon receptor II subtype b variant b delta 5.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/Swiss-Prot
    P20693
    UniProtKB/TrEMBL
    Q8VH33
    Conserved Domains (2) summary
    cd03590
    Location:164284
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl02576
    Location:55124
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  5. NM_001253746.1NP_001240675.1  low affinity immunoglobulin epsilon Fc receptor isoform F

    See proteins identical to NP_001240675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform F) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform F has also been called Fc epsilon receptor II subtype b variant b delta 6.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/Swiss-Prot
    P20693
    UniProtKB/TrEMBL
    Q8VH32
    Conserved Domains (2) summary
    cd03590
    Location:164284
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl17108
    Location:70127
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  6. NM_001253747.1NP_001240676.1  low affinity immunoglobulin epsilon Fc receptor isoform G

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform G) is shorter when it is compared to isoform A.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/Swiss-Prot
    P20693
    Conserved Domains (2) summary
    cd03590
    Location:146266
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl00143
    Location:2299
    Syntaxin; Syntaxin
  7. NM_013517.4NP_038545.1  low affinity immunoglobulin epsilon Fc receptor isoform A

    See proteins identical to NP_038545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).
    Source sequence(s)
    AC087183, M34163
    Consensus CDS
    CCDS22071.1
    UniProtKB/Swiss-Prot
    P20693
    Related
    ENSMUSP00000005678, ENSMUST00000005678
    Conserved Domains (2) summary
    cd03590
    Location:186306
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl00143
    Location:62139
    Syntaxin; Syntaxin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000074.6 

    Range
    3681737..3694174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508697.1XP_006508760.1  

    Conserved Domains (2) summary
    cd03590
    Location:190310
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl00143
    Location:66143
    Syntaxin; Syntaxin

Alternate Mm_Celera

Genomic

  1. AC_000030.1 

    Range
    3912066..3924335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)