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    Tlr4 toll-like receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 21898, updated on 28-Jun-2015
    Official Symbol
    Tlr4provided by MGI
    Official Full Name
    toll-like receptor 4provided by MGI
    Primary source
    MGI:MGI:96824
    See related
    Ensembl:ENSMUSG00000039005; Vega:OTTMUSG00000000227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lps; Ly87; Ran/M1; Rasl2-8
    Orthologs
    See Tlr4 in Epigenomics, MapViewer
    Location:
    4 C1; 4 34.66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (66827811..66842797)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (66488845..66503831)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene predicted gene, 31533 Neighboring gene predicted gene 11220 Neighboring gene high mobility group box 1, related sequence 18 Neighboring gene ribosomal protein S2 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell proliferation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    I-kappaB phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of NF-kappaB-inducing kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lipoteichoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    detection of lipopolysaccharide TAS
    Traceable Author Statement
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response-activating signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    interferon-gamma production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intestinal epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    mast cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-23 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nitric oxide production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of MHC class II biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-alpha production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-beta biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-1 biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of interleukin-1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-12 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-13 biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of interleukin-6 biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of interleukin-8 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric-oxide synthase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendritic cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    toll-like receptor 4
    Names
    toll-like receptor 4
    lipopolysaccharide response

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021297.2NP_067272.1  toll-like receptor 4 precursor

      See identical proteins and their annotated locations for NP_067272.1

      Status: PROVISIONAL

      Source sequence(s)
      BX649609
      Consensus CDS
      CCDS18271.1
      UniProtKB/TrEMBL
      L0CL36
      UniProtKB/Swiss-Prot
      Q9QUK6
      Related
      ENSMUSP00000045770, OTTMUSP00000000296, ENSMUST00000048096, OTTMUST00000000668
      Conserved Domains (3) summary
      cd00116
      Location:369555
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam01582
      Location:674812
      TIR; TIR domain
      pfam13855
      Location:494554
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

      Range
      66827811..66842797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000026.1 Alternate Mm_Celera

      Range
      65431141..65446127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)