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ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide [ Homo sapiens (human) ]

Gene ID: 126, updated on 26-Aug-2014
Official Symbol
ADH1Cprovided by HGNC
Official Full Name
alcohol dehydrogenase 1C (class I), gamma polypeptideprovided by HGNC
Primary source
HGNC:251
See related
Ensembl:ENSG00000248144; HPRD:00066; MIM:103730; Vega:OTTHUMG00000161422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADH3
Summary
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
See ADH1C in Epigenomics, MapViewer
Location:
4q23
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (99336492..99352760, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100257649..100273917, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507053 Neighboring gene alcohol dehydrogenase 1A (class I), alpha polypeptide Neighboring gene alcohol dehydrogenase 1B (class I), beta polypeptide Neighboring gene uncharacterized LOC102723576 Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Alcohol dependence
MedGen: CN028882 OMIM: 103780 GeneReviews: Not available
Compare labs
Parkinson's disease Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
NHGRI GWA Catalog
Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
NHGRI GWA Catalog
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
NHGRI GWA Catalog
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alcohol dehydrogenase (NAD) activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ethanol oxidation IDA
Inferred from Direct Assay
more info
PubMed 
ethanol oxidation TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
alcohol dehydrogenase 1C
Names
alcohol dehydrogenase 1C
ADH, gamma subunit
aldehyde reductase
alcohol dehydrogenase 3 (class I), gamma polypeptide
NP_000660.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011718.1 

    Range
    4716..21269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000669.4NP_000660.1  alcohol dehydrogenase 1C

    See proteins identical to NP_000660.1

    Status: REVIEWED

    Source sequence(s)
    BC074786, CD014078, DA562068
    UniProtKB/Swiss-Prot
    P00326
    Related
    ENSP00000426083, OTTHUMP00000220209, ENST00000515683, OTTHUMT00000364877
    Conserved Domains (2) summary
    cd08299
    Location:3375
    Blast Score: 2047
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
    COG1062
    Location:8375
    Blast Score: 1296
    AdhC; Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    99336492..99352760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    95995418..96011667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    100234034..100250392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)