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IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 [ Homo sapiens (human) ]

Gene ID: 3613, updated on 21-Mar-2015
Official Symbol
IMPA2provided by HGNC
Official Full Name
inositol(myo)-1(or 4)-monophosphatase 2provided by HGNC
Primary source
HGNC:HGNC:6051
See related
Ensembl:ENSG00000141401; HPRD:09329; MIM:605922; Vega:OTTHUMG00000131693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Orthologs
See IMPA2 in MapViewer
Location:
18p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (11981428..12030886)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (11981427..12030885)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type Neighboring gene uncharacterized LOC101927511 Neighboring gene metallophosphoesterase 1 Neighboring gene G protein-coupled receptor 125 pseudogene Neighboring gene single stranded DNA binding protein 4 pseudogene Neighboring gene ankyrin repeat domain 62

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inositol monophosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol monophosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
inositol monophosphatase 2
Names
inositol monophosphatase 2
IMP 2
IMPase 2
inosine monophosphatase 2
inositol monophosphatase 2 variant 1
inositol monophosphatase 2 variant 2
myo-inositol monophosphatase A2
NP_055029.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028104.1 RefSeqGene

    Range
    4973..54431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014214.2NP_055029.1  inositol monophosphatase 2

    See proteins identical to NP_055029.1

    Status: REVIEWED

    Source sequence(s)
    AF014398, AP001269, BC017176, BE219864
    Consensus CDS
    CCDS11855.1
    UniProtKB/Swiss-Prot
    O14732
    Related
    ENSP00000269159, OTTHUMP00000162474, ENST00000269159, OTTHUMT00000254601
    Conserved Domains (1) summary
    cd01639
    Location:19265
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    11981428..12030886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525661.1XP_011523963.1  

    Conserved Domains (1) summary
    cl00289
    Location:8145
    FIG; FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in ...
  2. XM_011525660.1XP_011523962.1  

    Conserved Domains (1) summary
    cd01639
    Location:8241
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
  3. XM_011525659.1XP_011523961.1  

    Conserved Domains (1) summary
    cd01639
    Location:62249
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    11981069..12030550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)