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Slc9a1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24782, updated on 14-Sep-2014
Official Symbol
Slc9a1provided by RGD
Official Full Name
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1provided by RGD
Primary source
RGD:3718
See related
Ensembl:ENSRNOG00000007982
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Nhe1
Summary
catalyzes the exchange of a proton with a sodium ion across the plasma membrane; plays a role in regulation of intracellular pH [RGD, Feb 2006]
See Slc9a1 in MapViewer
Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151573122..151626360)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (155237482..155290410)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 222 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC102548651 Neighboring gene family with sequence similarity 46, member B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:proton antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cardiac muscle cell contraction IEP
Inferred from Expression Pattern
more info
 
cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
cell growth IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to antibiotic IEP
Inferred from Expression Pattern
more info
 
cellular response to electrical stimulus IEP
Inferred from Expression Pattern
more info
 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 
hydrogen ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
hydrogen ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
 
regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
 
regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
regulation of intracellular pH ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of pH ISO
Inferred from Sequence Orthology
more info
 
regulation of pH ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 
regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
 
response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion export ISS
Inferred from Sequence or Structural Similarity
more info
 
sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
T-tubule IDA
Inferred from Direct Assay
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intercalated disc IDA
Inferred from Direct Assay
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
NOT nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
 
Preferred Names
sodium/hydrogen exchanger 1
Names
sodium/hydrogen exchanger 1
NHE-1
Na(+)/H(+) exchanger 1
solute carrier family 9 member 1
solute carrier family 9, member 1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012652.1NP_036784.1  sodium/hydrogen exchanger 1

    See proteins identical to NP_036784.1

    Status: PROVISIONAL

    Source sequence(s)
    M85299
    UniProtKB/Swiss-Prot
    P26431
    Related
    ENSRNOP00000011049, ENSRNOT00000011049
    Conserved Domains (2) summary
    TIGR00840
    Location:99664
    Blast Score: 2169
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:111504
    Blast Score: 622
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 

    Range
    151573122..151626360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 

    Range
    143998303..144051177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)