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    Cxcl5 chemokine (C-X-C motif) ligand 5 [ Mus musculus (house mouse) ]

    Gene ID: 20311, updated on 3-Jan-2016
    Official Symbol
    Cxcl5provided by MGI
    Official Full Name
    chemokine (C-X-C motif) ligand 5provided by MGI
    Primary source
    MGI:MGI:1096868
    See related
    Ensembl:ENSMUSG00000029371; Vega:OTTMUSG00000055503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
    Summary
    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]
    See Cxcl5 in Epigenomics, MapViewer
    Location:
    5 E1; 5 44.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (90759298..90761625)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91188325..91190651)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 6 Neighboring gene predicted gene, 36084 Neighboring gene pro-platelet basic protein Neighboring gene platelet factor 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neutrophil mediated killing of gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    C-X-C motif chemokine 5
    Names
    cytokine LIX
    granulocyte chemotactic protein-2
    small inducible cytokine B subfamily, member 5
    small inducible cytokine subfamily B, member 15
    small-inducible cytokine B5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009141.3NP_033167.2  C-X-C motif chemokine 5 precursor

      See identical proteins and their annotated locations for NP_033167.2

      Status: REVIEWED

      Source sequence(s)
      AC105995, BQ829929
      Consensus CDS
      CCDS19414.1
      UniProtKB/Swiss-Prot
      P50228
      Related
      ENSMUSP00000031318, OTTMUSP00000072358, ENSMUST00000031318, OTTMUST00000137378
      Conserved Domains (1) summary
      cd00273
      Location:50111
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      90759298..90761625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p3 129S1/SvImJ

    Genomic

    1. NT_109599.1 Reference GRCm38.p3 129S1/SvImJ

      Range
      65104..67443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      88910983..88913251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)