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    MS4A1 membrane spanning 4-domains A1 [ Homo sapiens (human) ]

    Gene ID: 931, updated on 22-Sep-2016
    Official Symbol
    MS4A1provided by HGNC
    Official Full Name
    membrane spanning 4-domains A1provided by HGNC
    Primary source
    HGNC:HGNC:7315
    See related
    Ensembl:ENSG00000156738 HPRD:00204; MIM:112210; Vega:OTTHUMG00000167614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16
    Summary
    This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (60455809..60470752)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60223251..60238225)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A14 Neighboring gene membrane spanning 4-domains A5 Neighboring gene uncharacterized LOC105369320 Neighboring gene membrane spanning 4-domains A12 Neighboring gene membrane spanning 4-domains A13

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated plasmacytoid dendritic cells show a reduced capacity to stimulate B cell growth and differentiation through downregulation of CD20 and CD38 PubMed
    env HIV-1 gp120 downregulates CD79B from the surface of dual-positive CD79b/CD20 B cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: MS4A5

    Homology

    Clone Names

    • MGC3969

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    MHC class II protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    humoral immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    B-lymphocyte antigen CD20
    Names
    B-lymphocyte cell-surface antigen B1
    CD20 antigen
    CD20 receptor
    leukocyte surface antigen Leu-16
    membrane-spanning 4-domains, subfamily A, member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023388.1 RefSeqGene

      Range
      5001..19944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_140

    mRNA and Protein(s)

    1. NM_021950.3NP_068769.2  B-lymphocyte antigen CD20

      See identical proteins and their annotated locations for NP_068769.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' UTR, compared to variant 1, but encodes the same protein.
      Source sequence(s)
      AP001034, BC002807, CD691924
      Consensus CDS
      CCDS31570.1
      UniProtKB/Swiss-Prot
      P11836
      UniProtKB/TrEMBL
      A0A024R507
      Related
      ENSP00000314620, ENST00000345732
      Conserved Domains (1) summary
      pfam04103
      Location:51216
      CD20; CD20-like family
    2. NM_152866.2NP_690605.1  B-lymphocyte antigen CD20

      See identical proteins and their annotated locations for NP_690605.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript variant. Variants 1 and 3 both encode the same protein.
      Source sequence(s)
      AP001034, AW504475, BC002807, CD691924
      Consensus CDS
      CCDS31570.1
      UniProtKB/Swiss-Prot
      P11836
      UniProtKB/TrEMBL
      A0A024R507
      Conserved Domains (1) summary
      pfam04103
      Location:51216
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      60455809..60470752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      60089320..60104266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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