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Chrna7 cholinergic receptor, nicotinic, alpha 7 (neuronal) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25302, updated on 14-Sep-2014
Official Symbol
Chrna7provided by RGD
Official Full Name
cholinergic receptor, nicotinic, alpha 7 (neuronal)provided by RGD
Primary source
RGD:2348
See related
Ensembl:ENSRNOG00000010853
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
BTX; NARAD; nAChRa7
Summary
subunit of nicotinic acetylcholline receptor; may mediate nicotine induced increase in tyrosine hydroxylase expression; may play a role in neuroprotection [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
See Chrna7 in MapViewer
Location:
1q22
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (123898305..124039253, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (125029451..125158153, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548067 Neighboring gene F-box/WD repeat-containing protein 11-like Neighboring gene ANKRD26-like family C, member 2 Neighboring gene uncharacterized LOC102548165 Neighboring gene uncharacterized LOC102548323

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Chemical carcinogenesis, organism-specific biosystem (from KEGG)
    Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Chemical carcinogenesis, conserved biosystem (from KEGG)
    Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nicotine addiction, organism-specific biosystem (from KEGG)
    Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
  • Nicotine addiction, conserved biosystem (from KEGG)
    Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATPase binding IDA
Inferred from Direct Assay
more info
 
acetylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetylcholine binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
 
acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-activated cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine-activated cation-selective channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetylcholine-activated cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-gated cation channel activity IEA
Inferred from Electronic Annotation
more info
 
acetylcholine-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-amyloid binding IEA
Inferred from Electronic Annotation
more info
 
beta-amyloid binding ISO
Inferred from Sequence Orthology
more info
 
chloride channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
chloride channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IDA
Inferred from Direct Assay
more info
 
toxic substance binding IEA
Inferred from Electronic Annotation
more info
 
toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell activation IEA
Inferred from Electronic Annotation
more info
 
B cell activation ISO
Inferred from Sequence Orthology
more info
 
T cell activation IEA
Inferred from Electronic Annotation
more info
 
T cell activation ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
associative learning IEA
Inferred from Electronic Annotation
more info
 
associative learning ISO
Inferred from Sequence Orthology
more info
 
behavioral response to ethanol IEA
Inferred from Electronic Annotation
more info
 
behavioral response to ethanol ISO
Inferred from Sequence Orthology
more info
 
behavioral response to nicotine IEA
Inferred from Electronic Annotation
more info
 
behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cognition ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
generation of ovulation cycle rhythm IEA
Inferred from Electronic Annotation
more info
 
generation of ovulation cycle rhythm ISO
Inferred from Sequence Orthology
more info
 
ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
ion transport ISO
Inferred from Sequence Orthology
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential IDA
Inferred from Direct Assay
more info
PubMed 
neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
ovulation cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
response to food ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
sperm motility IEA
Inferred from Electronic Annotation
more info
 
sperm motility ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine-gated channel complex IMP
Inferred from Mutant Phenotype
more info
 
acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-gated channel complex TAS
Traceable Author Statement
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
neuronal acetylcholine receptor subunit alpha-7
Names
neuronal acetylcholine receptor subunit alpha-7
bungarotoxin alpha
nicotinic receptor alpha 7 subunit
neuronal nicotinic acetycholine receptor alpha 7
cholinergic receptor, nicotinic, alpha polypeptide 7
C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012832.3NP_036964.3  neuronal acetylcholine receptor subunit alpha-7 precursor

    See proteins identical to NP_036964.3

    Status: PROVISIONAL

    Source sequence(s)
    AY574256
    UniProtKB/Swiss-Prot
    Q05941
    Related
    ENSRNOP00000045255, ENSRNOT00000051883
    Conserved Domains (3) summary
    TIGR00860
    Location:4490
    LIC; Cation transporter family protein
    pfam02931
    Location:26230
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:237486
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 

    Range
    123898305..124039253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759498.1XP_008757720.1  

    See proteins identical to XP_008757720.1

    Conserved Domains (3) summary
    TIGR00860
    Location:4519
    LIC; Cation transporter family protein
    pfam02931
    Location:26259
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:266515
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  2. XM_008759497.1XP_008757719.1  

    Conserved Domains (2) summary
    pfam02931
    Location:2140
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:147396
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

Alternate Rn_Celera

Genomic

  1. AC_000069.1 

    Range
    108976664..109097764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)