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    PARP1 poly(ADP-ribose) polymerase 1 [ Homo sapiens (human) ]

    Gene ID: 142, updated on 22-Aug-2016
    Official Symbol
    PARP1provided by HGNC
    Official Full Name
    poly(ADP-ribose) polymerase 1provided by HGNC
    Primary source
    HGNC:HGNC:270
    See related
    Ensembl:ENSG00000143799 HPRD:01435; MIM:173870; Vega:OTTHUMG00000037556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
    Summary
    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q41-q42
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (226360691..226408100, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226548392..226595801, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Y-box binding protein 1 pseudogene 9 Neighboring gene signal peptidase complex subunit 3-like Neighboring gene ribosomal protein S3a pseudogene 7 Neighboring gene RNA, 7SK small nuclear pseudogene 165

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    HIV-1 replication is enhanced by PARP1 in monocyte derived macrophages PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
    env Contact of CD4+ T cells with HIV-1 infected or HIV-1 gp120-expressing cells induces PARP hydrolysis, which leads to the cleavage of 116 kDa PARP into two fragments PubMed
    Nef nef HIV-1 Nef enhances apoptosis in CD4+ T lymphoblastoid cell lines through mechanisms that include the cleavage of the caspase target poly(ADP-ribose) polymerase PubMed
    nef Expression of HIV-1 Nef in human brain micro vascular endothelial cells induces the cleavage of PARP protein, which is involved in DNA repair PubMed
    Tat tat HIV-1 clade B and C Tat induces cleavage of both PARP and CASP3 in primary glia PubMed
    tat HIV-1 Tat-induced PARP cleavage during mitotic arrest occurs downstream of Tat-induced cytochrome c release during mitotic arrest in CD4+ T-lymphocytes PubMed
    tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed
    tat The levels of PARP1 protein are reduced after Caco-2 cells exposure to HIV-1 Tat compared with control PubMed
    tat PARP1 negatively regulates HIV-1 transcription by directly competing with Tat-P-TEFb complex for binding to TAR RNA PubMed
    tat HIV-1 Tat induces the cleavage of PARP and activation of apoptosis through a p56lck dependent mechanism PubMed
    tat Treatment of primary human microvascular endothelial cells of lung origin with HIV-1 Tat caused cleavage of poly(A/DP)-ribose polymerase as a result of caspase activation PubMed
    tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed
    tat Poly(ADP-ribose) polymerase modifies HIV-1 Tat with poly(ADP-ribose), suggesting a role for this enzyme in the regulation of HIV-1 gene expression PubMed
    tat Purified recombinant HIV-1 Tat protein stimulates poly(ADP-ribose) polymerase in a dose dependent manner PubMed
    Vpr vpr Recruitment of PARP-1 by HIV-1 Vpr-glucocorticoid receptor (GR) complex prevents its nuclear localization, which is necessary for Vpr to suppress NF-kappaB PubMed
    vpr HIV-1 Vpr induces apoptosis and the cleavage of ADPRT in a manner that is signaled through the DNA damage signaling protein ataxia telangiectasia Rad3-related protein (ATR) PubMed
    Vpu vpu HIV-1 Vpu-induced cleavage of PARP is dependent on caspase activity in cells PubMed
    integrase gag-pol PARP has been described as a requirement for efficient HIV-1 integration, however a conflicting report indicates it is not essential for efficient lentivirus integration PubMed
    retropepsin gag-pol Inhibition of HIV-1 protease by saquinavir and leu3.a blocks PARP cleavage and protects cells from apoptosis and necrosis PubMed
    gag-pol Positional proteomics analysis identifies the cleavage of human poly (ADP-ribose) polymerase family, member 1 (PARP1) at amino acid residues 185-186 by the HIV-1 protease PubMed
    gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Interaction Database

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • BER complex, organism-specific biosystem (from KEGG)
      BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BER complex, conserved biosystem (from KEGG)
      BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
    • Base Excision Repair, organism-specific biosystem (from REACTOME)
      Base Excision Repair, organism-specific biosystemOf the three major pathways involved in the repair of nucleotide damage in DNA, base excision repair (BER) involves the greatest number of individual enzymatic activities. This is the consequence of ...
    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Corticotropin-releasing hormone, organism-specific biosystem (from WikiPathways)
      Corticotropin-releasing hormone, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
    • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
      DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
    • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
      DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
    • DNA Repair, organism-specific biosystem (from REACTOME)
      DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
    • Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystem (from REACTOME)
      Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystemTranscriptional activity of SMAD2/3:SMAD4 heterotrimer can be inhibited by formation of a complex with SKI or SKIL (SNO), where SKI or SKIL recruit NCOR and possibly other transcriptional repressors ...
    • Dual Incision in GG-NER, organism-specific biosystem (from REACTOME)
      Dual Incision in GG-NER, organism-specific biosystemDouble incision at the damaged DNA strand excises the oligonucleotide that contains the lesion from the open bubble. The excised oligonucleotide is ~27-30 bases long. Incision 5' to the damage site, ...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • Formation of Incision Complex in GG-NER, organism-specific biosystem (from REACTOME)
      Formation of Incision Complex in GG-NER, organism-specific biosystemAfter the XPC complex and the UV-DDB complex bind damaged DNA, a basal transcription factor TFIIH is recruited to the nucleotide excision repair (NER) site (Volker et al. 2001, Riedl et al. 2003). DN...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
      Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
    • HDR through MMEJ (alt-NHEJ), organism-specific biosystem (from REACTOME)
      HDR through MMEJ (alt-NHEJ), organism-specific biosystemHomology directed repair (HDR) through microhomology-mediated end joining (MMEJ) is an error prone process also known as alternative nonhomologous end joining (alt-NHEJ), although it does not involve...
    • Homology Directed Repair, organism-specific biosystem (from REACTOME)
      Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
      Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
    • POLB-Dependent Long Patch Base Excision Repair, organism-specific biosystem (from REACTOME)
      POLB-Dependent Long Patch Base Excision Repair, organism-specific biosystemDuring POLB-dependent long patch base excision repair (BER), PARP1 and/or PARP2 is recruited to the BER site along with flap endonuclease FEN1. PARP1 and/or PARP2 and FEN1 facilitate POLB-mediated st...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystem (from REACTOME)
      Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystemWhile the single nucleotide replacement pathway appears to facilitate the repair of most damaged bases, an alternative BER pathway is evoked when the structure of the 5'-terminal sugar phosphate is s...
    • Resolution of Abasic Sites (AP sites), organism-specific biosystem (from REACTOME)
      Resolution of Abasic Sites (AP sites), organism-specific biosystemResolution of AP sites can occur through the single nucleotide replacement pathway or through the multiple nucleotide patch replacement pathway, also known as the long-patch base excision repair (BER...
    • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
      SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
    • SUMOylation, organism-specific biosystem (from REACTOME)
      SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
    • SUMOylation of DNA damage response and repair proteins, organism-specific biosystem (from REACTOME)
      SUMOylation of DNA damage response and repair proteins, organism-specific biosystemSeveral factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferr...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
      Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
    • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystem (from REACTOME)
      Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystemIn the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcrip...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    R-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP generation from poly-ADP-D-ribose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA damage response, detection of DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    DNA ligation involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
     
    global genome nucleotide-excision repair TAS
    Traceable Author Statement
    more info
     
    lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    macrophage differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, DNA damage recognition TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, DNA duplex unwinding TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, DNA incision TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, DNA incision, 3'-to lesion TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, DNA incision, 5'-to lesion TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, preincision complex assembly TAS
    Traceable Author Statement
    more info
     
    nucleotide-excision repair, preincision complex stabilization TAS
    Traceable Author Statement
    more info
     
    positive regulation of SMAD protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
     
    protein modification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein poly-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein sumoylation TAS
    Traceable Author Statement
    more info
     
    regulation of cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
     
    signal transduction involved in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
    ADP-ribosyltransferase NAD(+)
    ADP-ribosyltransferase diphtheria toxin-like 1
    NAD(+) ADP-ribosyltransferase 1
    poly (ADP-ribose) polymerase 1
    poly (ADP-ribose) polymerase family, member 1
    poly(ADP-ribose) polymerase
    poly(ADP-ribose) synthetase
    poly(ADP-ribosyl)transferase
    poly[ADP-ribose] synthase 1
    NP_001609.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001618.3NP_001609.2  poly [ADP-ribose] polymerase 1

      See identical proteins and their annotated locations for NP_001609.2

      Status: REVIEWED

      Source sequence(s)
      AK225654, BC037545, DB097441, J03473
      Consensus CDS
      CCDS1554.1
      UniProtKB/Swiss-Prot
      P09874
      UniProtKB/TrEMBL
      A0A024R3T8
      Related
      ENSP00000355759, OTTHUMP00000035663, ENST00000366794, OTTHUMT00000091519
      Conserved Domains (6) summary
      cd08001
      Location:543645
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:61010
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd00027
      Location:392461
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd01437
      Location:6621006
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00645
      Location:1290
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:279332
      PADR1; PADR1 (NUC008) domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      226360691..226408100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      227821256..227868667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)