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Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 223701, updated on 23-Nov-2014
Official Symbol
Mkl1provided by MGI
Official Full Name
MKL (megakaryoblastic leukemia)/myocardin-like 1provided by MGI
Primary source
MGI:MGI:2384495
See related
Ensembl:ENSMUSG00000042292; Vega:OTTMUSG00000034068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mal; AMKL; Bsac; Mrtf-A
See Mkl1 in Epigenomics, MapViewer
Location:
15 E1; 15
Exon count:
16
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (81012281..81190757, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 pseudogene Neighboring gene adenylosuccinate lyase Neighboring gene small G protein signaling modulator 3 Neighboring gene predicted gene, 31462 Neighboring gene RIKEN cDNA 4930483J18 gene Neighboring gene 60S ribosomal protein L27a-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding ISO
Inferred from Sequence Orthology
more info
 
actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
MKL/myocardin-like protein 1
Names
MKL/myocardin-like protein 1
basic SAP and coiled-coil domains
myocardin-related transcription factor A
basic SAP coiled-coil transcription activator
megakaryoblastic leukemia (translocation) 1 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082536.1NP_001076005.1  MKL/myocardin-like protein 1 isoform 2

    See proteins identical to NP_001076005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF532597, BC050941, BC054801, BY750304
    Consensus CDS
    CCDS49674.1
    UniProtKB/Swiss-Prot
    Q8K4J6
    Related
    ENSMUSP00000117745, OTTMUSP00000046545, ENSMUST00000149582, OTTMUST00000086059
    Conserved Domains (4) summary
    smart00707
    Location:6893
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:350383
    SAP; SAP domain
    pfam02755
    Location:2449
    RPEL; RPEL repeat
    pfam04394
    Location:525565
    DUF536; Protein of unknown function, DUF536
  2. NM_153049.3NP_694629.2  MKL/myocardin-like protein 1 isoform 1

    See proteins identical to NP_694629.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF532597, BC050941, BY208699
    Consensus CDS
    CCDS37147.1
    UniProtKB/Swiss-Prot
    Q8K4J6
    Related
    ENSMUSP00000105207, OTTMUSP00000046546, ENSMUST00000109579, OTTMUST00000086060
    Conserved Domains (4) summary
    smart00707
    Location:103128
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:385418
    SAP; SAP domain
    pfam02755
    Location:5984
    RPEL; RPEL repeat
    pfam04394
    Location:560600
    DUF536; Protein of unknown function, DUF536

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    81012281..81190757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520812.1XP_006520875.1  

    Conserved Domains (3) summary
    smart00707
    Location:1540
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:385418
    SAP; SAP domain
    pfam02755
    Location:5984
    RPEL; RPEL repeat

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    83132403..83308218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)