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MTERF1 mitochondrial transcription termination factor 1 [ Homo sapiens (human) ]

Gene ID: 7978, updated on 14-Sep-2014
Official Symbol
MTERF1provided by HGNC
Official Full Name
mitochondrial transcription termination factor 1provided by HGNC
Primary source
HGNC:HGNC:21463
See related
Ensembl:ENSG00000127989; HPRD:08373; MIM:602318; Vega:OTTHUMG00000156057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTERF
Summary
This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
See MTERF1 in Epigenomics, MapViewer
Location:
7q21.2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (91872707..91880702, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91502021..91510016, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927473 Neighboring gene non imprinted in Prader-Willi/Angelman syndrome 2 pseudogene 1 Neighboring gene A kinase (PRKA) anchor protein 9 Neighboring gene cytochrome P450, family 51, subfamily A, polypeptide 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC131634

Gene Ontology Provided by GOA

Function Evidence Code Pubs
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
DNA geometric change IDA
Inferred from Direct Assay
more info
 
DNA-templated transcription, termination IDA
Inferred from Direct Assay
more info
 
gene expression TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
termination of mitochondrial transcription IDA
Inferred from Direct Assay
more info
 
termination of mitochondrial transcription TAS
Traceable Author Statement
more info
 
transcription from mitochondrial promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
transcription termination factor 1, mitochondrial
Names
transcription termination factor 1, mitochondrial
transcription termination factor, mitochondrial

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301134.1NP_001288063.1  transcription termination factor 1, mitochondrial isoform 2

    See proteins identical to NP_001288063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK222730, AL832861, BC130391, BU740531
    Consensus CDS
    CCDS75629.1
    Conserved Domains (1) summary
    pfam02536
    Location:53376
    mTERF; mTERF
  2. NM_001301135.1NP_001288064.1  transcription termination factor 1, mitochondrial isoform 2

    See proteins identical to NP_001288064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK222730, AK298469, BU740531
    Consensus CDS
    CCDS75629.1
    Conserved Domains (1) summary
    pfam02536
    Location:53376
    mTERF; mTERF
  3. NM_006980.4NP_008911.1  transcription termination factor 1, mitochondrial isoform 1 precursor

    See proteins identical to NP_008911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK222730, BC130391, BU740531
    Consensus CDS
    CCDS5621.1
    UniProtKB/Swiss-Prot
    Q99551
    Related
    ENSP00000248643, OTTHUMP00000209142, ENST00000351870, OTTHUMT00000342896
    Conserved Domains (1) summary
    pfam02536
    Location:73396
    mTERF; mTERF

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    91872707..91880702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250594.1XP_005250651.1  

    UniProtKB/TrEMBL
    B4DPR9
    Conserved Domains (1) summary
    pfam02536
    Location:53376
    mTERF; mTERF
  2. XM_005250593.1XP_005250650.1  

    See proteins identical to XP_005250650.1

    UniProtKB/Swiss-Prot
    Q99551
    Conserved Domains (1) summary
    pfam02536
    Location:73396
    mTERF; mTERF
  3. XM_005250595.1XP_005250652.1  

    UniProtKB/TrEMBL
    B4DPR9
    Conserved Domains (1) summary
    pfam02536
    Location:53376
    mTERF; mTERF
  4. XM_006716126.1XP_006716189.1  

    See proteins identical to XP_006716189.1

    UniProtKB/Swiss-Prot
    Q99551
    Conserved Domains (1) summary
    pfam02536
    Location:73396
    mTERF; mTERF

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    86109784..86117779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    91432061..91440056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)