Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    ARNTL aryl hydrocarbon receptor nuclear translocator like [ Homo sapiens (human) ]

    Gene ID: 406, updated on 24-Apr-2016
    Official Symbol
    ARNTLprovided by HGNC
    Official Full Name
    aryl hydrocarbon receptor nuclear translocator likeprovided by HGNC
    Primary source
    HGNC:HGNC:701
    See related
    Ensembl:ENSG00000133794 HPRD:03973; MIM:602550; Vega:OTTHUMG00000150623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5
    Summary
    The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Orthologs
    Location:
    11p15
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (13277727..13387811)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (13299325..13408813)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376558 Neighboring gene uncharacterized LOC105376560 Neighboring gene uncharacterized LOC105376559 Neighboring gene uncharacterized LOC101928110 Neighboring gene BTB domain containing 10 Neighboring gene ret finger protein-like 4A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
    NHGRI GWA Catalog
    Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
    NHGRI GWA Catalog
    Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of aryl hydrocarbon receptor nuclear translocator-like (ARNTL) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
      BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
    • Circadian rhythm, organism-specific biosystem (from KEGG)
      Circadian rhythm, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Circadian rhythm, conserved biosystem (from KEGG)
      Circadian rhythm, conserved biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In mammals, the circadian clock mechanism consists of ...
    • Circadian rhythm pathway, organism-specific biosystem (from Pathway Interaction Database)
      Circadian rhythm pathway, organism-specific biosystem
      Circadian rhythm pathway
    • Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
      Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • RORA activates gene expression, organism-specific biosystem (from REACTOME)
      RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC47515

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aryl hydrocarbon receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    bHLH transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcriptional activator activity, RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm TAS
    Traceable Author Statement
    more info
     
    maternal process involved in parturition IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glucocorticoid receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidative stress-induced premature senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of skeletal muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of hair cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of type B pancreatic cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to redox state IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    chromatoid body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Preferred Names
    aryl hydrocarbon receptor nuclear translocator-like protein 1
    Names
    ARNT-like protein 1, brain and muscle
    PAS domain-containing protein 3
    bHLH-PAS protein JAP3
    basic-helix-loop-helix-PAS orphan MOP3
    basic-helix-loop-helix-PAS protein MOP3
    brain and muscle ARNT-like 1
    class E basic helix-loop-helix protein 5
    member of PAS protein 3
    member of PAS superfamily 3
    testis tissue sperm-binding protein Li 50e

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030272.2NP_001025443.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001025443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (a) is 1 aa shorter compared to isoform c. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK291510, BC041129, BE391243
      Consensus CDS
      CCDS31430.1
      UniProtKB/Swiss-Prot
      O00327
      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:340435
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:338440
      PAS_11; PAS domain
    2. NM_001030273.2NP_001025444.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_001025444.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (b) has a shorter and distinct N-terminus and lacks an alternate internal aa compared to isoform c.
      Source sequence(s)
      AF044288, AK095749, BE391243
      Consensus CDS
      CCDS44543.1
      UniProtKB/Swiss-Prot
      O00327
      Related
      ENSP00000385581, OTTHUMP00000197998, ENST00000403510, OTTHUMT00000319171
      Conserved Domains (4) summary
      cd00083
      Location:2883
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:297392
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:103210
      PAS; PAS fold
      pfam14598
      Location:295397
      PAS_11; PAS domain
    3. NM_001178.5NP_001169.3  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001169.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 4. The resulting isoform (a) is 1 aa shorter compared to isoform c. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      BC041129, BE391243
      Consensus CDS
      CCDS31430.1
      UniProtKB/Swiss-Prot
      O00327
      Related
      ENSP00000374357, OTTHUMP00000197997, ENST00000389707, OTTHUMT00000319170
      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:340435
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:338440
      PAS_11; PAS domain
    4. NM_001297719.1NP_001284648.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

      See identical proteins and their annotated locations for NP_001284648.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (c). Variants 4 and 5 both encode the same isoform (c).
      Source sequence(s)
      AC016884, AF044288, AK315174, BE391243
      Consensus CDS
      CCDS73259.1
      UniProtKB/Swiss-Prot
      O00327
      UniProtKB/TrEMBL
      B2RCL8
      Related
      ENSP00000384517, OTTHUMP00000198000, ENST00000403290, OTTHUMT00000319173
      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:341436
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:339441
      PAS_11; PAS domain
    5. NM_001297722.1NP_001284651.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform c

      See identical proteins and their annotated locations for NP_001284651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 4 and 5 both encode the same isoform (c).
      Source sequence(s)
      AF044288, AK291510, BE391243
      Consensus CDS
      CCDS73259.1
      UniProtKB/Swiss-Prot
      O00327
      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:341436
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:339441
      PAS_11; PAS domain
    6. NM_001297724.1NP_001284653.1  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform d

      See identical proteins and their annotated locations for NP_001284653.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate exon compared to variant 4. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform c.
      Source sequence(s)
      BC031214, BE391243
      Consensus CDS
      CCDS76387.1
      UniProtKB/Swiss-Prot
      O00327
      Related
      ENSP00000385915, OTTHUMP00000197999, ENST00000401424, OTTHUMT00000319172
      Conserved Domains (4) summary
      cd00083
      Location:2883
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:298393
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:103210
      PAS; PAS fold
      pfam14598
      Location:296398
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      13277727..13387811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520108.1XP_011518410.1  

      See identical proteins and their annotated locations for XP_011518410.1

      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:341436
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:339441
      PAS_11; PAS domain
    2. XM_011520112.1XP_011518414.1  

      See identical proteins and their annotated locations for XP_011518414.1

      UniProtKB/Swiss-Prot
      O00327
      Conserved Domains (4) summary
      cd00083
      Location:2883
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:298393
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:103210
      PAS; PAS fold
      pfam14598
      Location:296398
      PAS_11; PAS domain
    3. XM_011520110.1XP_011518412.1  

      See identical proteins and their annotated locations for XP_011518412.1

      Conserved Domains (4) summary
      cd00083
      Location:2883
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:298393
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:103210
      PAS; PAS fold
      pfam14598
      Location:296398
      PAS_11; PAS domain
    4. XM_011520113.1XP_011518415.1  

      See identical proteins and their annotated locations for XP_011518415.1

      UniProtKB/Swiss-Prot
      O00327
      Conserved Domains (4) summary
      cd00083
      Location:2883
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:297392
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:103210
      PAS; PAS fold
      pfam14598
      Location:295397
      PAS_11; PAS domain
    5. XM_006718234.1XP_006718297.1  

      See identical proteins and their annotated locations for XP_006718297.1

      Conserved Domains (4) summary
      cd00083
      Location:2883
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:298393
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:103210
      PAS; PAS fold
      pfam14598
      Location:296398
      PAS_11; PAS domain
    6. XM_006718233.2XP_006718296.1  

      See identical proteins and their annotated locations for XP_006718296.1

      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:341436
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:339441
      PAS_11; PAS domain
    7. XM_011520111.1XP_011518413.1  

      See identical proteins and their annotated locations for XP_011518413.1

      Conserved Domains (4) summary
      cd00083
      Location:2883
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:298393
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:103210
      PAS; PAS fold
      pfam14598
      Location:296398
      PAS_11; PAS domain
    8. XM_011520109.1XP_011518411.1  

      See identical proteins and their annotated locations for XP_011518411.1

      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:341436
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:339441
      PAS_11; PAS domain
    9. XM_011520106.1XP_011518408.1  

      See identical proteins and their annotated locations for XP_011518408.1

      UniProtKB/Swiss-Prot
      O00327
      Related
      ENSP00000385897, OTTHUMP00000198001, ENST00000403482, OTTHUMT00000319174
      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:341436
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:339441
      PAS_11; PAS domain
    10. XM_011520105.1XP_011518407.1  

      See identical proteins and their annotated locations for XP_011518407.1

      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:340435
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:338440
      PAS_11; PAS domain
    11. XM_011520107.1XP_011518409.1  

      See identical proteins and their annotated locations for XP_011518409.1

      UniProtKB/Swiss-Prot
      O00327
      Conserved Domains (4) summary
      cd00083
      Location:71126
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:340435
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00989
      Location:146253
      PAS; PAS fold
      pfam14598
      Location:338440
      PAS_11; PAS domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      13298251..13407784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)