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    Il7 interleukin 7 [ Mus musculus (house mouse) ]

    Gene ID: 16196, updated on 7-Feb-2016
    Official Symbol
    Il7provided by MGI
    Official Full Name
    interleukin 7provided by MGI
    Primary source
    MGI:MGI:96561
    See related
    Ensembl:ENSMUSG00000040329; Vega:OTTMUSG00000051379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-7; hlb368; A630026I06Rik
    Summary
    The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    3 A1; 3 2.02 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (7572028..7613427, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (7572077..7613427, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 pseudogene Neighboring gene zinc finger, C2HC-type containing 1A Neighboring gene uncharacterized LOC102634900 Neighboring gene predicted gene, 41992 Neighboring gene RIKEN cDNA 1700010I02 gene Neighboring gene predicted gene, 29747

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Clone Names

    • MGC129342

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-7 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313888.1NP_001300817.1  interleukin-7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon near the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (b) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK040399, AK052452
      UniProtKB/TrEMBL
      Q3UT18
      Conserved Domains (1) summary
      cl11602
      Location:1111
      IL7; Interleukin 7/9 family
    2. NM_001313889.1NP_001300818.1  interleukin-7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon near the 5' end and an alternate internal exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK040399, AK042009, AK052452
      Conserved Domains (1) summary
      cl11602
      Location:1102
      IL7; Interleukin 7/9 family
    3. NM_001313890.1NP_001300819.1  interleukin-7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains two alternate exons in place of the first exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AK040399, AK139858
      UniProtKB/TrEMBL
      Q3UT18
      Conserved Domains (1) summary
      cl11602
      Location:1111
      IL7; Interleukin 7/9 family
    4. NM_008371.5NP_032397.1  interleukin-7 isoform a precursor

      See identical proteins and their annotated locations for NP_032397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK040399, AK041307, AK052452
      Consensus CDS
      CCDS50859.1
      UniProtKB/Swiss-Prot
      P10168
      UniProtKB/TrEMBL
      Q544C8
      Conserved Domains (1) summary
      smart00127
      Location:27152
      IL7; Interleukin-7 and interleukin-9 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

      Range
      7572028..7613427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530054.2XP_006530117.1  

      Related
      ENSMUSP00000126219, OTTMUSP00000069724, ENSMUST00000168269, OTTMUST00000129913
      Conserved Domains (1) summary
      cl11602
      Location:1102
      IL7; Interleukin 7/9 family

    Alternate Mm_Celera

    Genomic

    1. AC_000025.1 Alternate Mm_Celera

      Range
      7588657..7629776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)