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Clcn5 chloride channel 5 [ Mus musculus (house mouse) ]

Gene ID: 12728, updated on 20-Jan-2015
Official Symbol
Clcn5provided by MGI
Official Full Name
chloride channel 5provided by MGI
Primary source
MGI:MGI:99486
Locus tag
RP23-146I4.3
See related
Ensembl:ENSMUSG00000004317; Vega:OTTMUSG00000016484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clc5; ClC-5; Sfc13; T25545; DXImx42e; 5430408K11Rik; D930009B12Rik
Orthologs
See Clcn5 in MapViewer
Location:
X A1.1; X 3.21 cM
Exon count:
18
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (7153810..7319364, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene A kinase (PRKA) anchor protein 4 Neighboring gene ribosomal protein L23a pseudogene Neighboring gene microRNA 500 Neighboring gene microRNA 501 Neighboring gene microRNA 362 Neighboring gene microRNA 188 Neighboring gene microRNA 532 Neighboring gene predicted gene 14379 Neighboring gene ubiquitin specific peptidase 27, X chromosome

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
antiporter activity IEA
Inferred from Electronic Annotation
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
voltage-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
chloride transport ISO
Inferred from Sequence Orthology
more info
 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of anion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
H(+)/Cl(-) exchange transporter 5
Names
H(+)/Cl(-) exchange transporter 5
chloride channel protein 5
chloride transporter ClC-5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243762.1NP_001230691.1  H(+)/Cl(-) exchange transporter 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate exons in the 5' UTR and 5' CDS, compared to variant 1. It encodes isoform 2, which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL663104, AL808124
    Consensus CDS
    CCDS57727.1
    UniProtKB/TrEMBL
    B1ATV0
    Conserved Domains (3) summary
    COG0517
    Location:653799
    COG0517; FOG: CBS domain [General function prediction only]
    cd03684
    Location:142640
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:665801
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
  2. NM_016691.4NP_057900.3  H(+)/Cl(-) exchange transporter 5 isoform 1

    See proteins identical to NP_057900.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AF134117, AK052990, AK145763, AL808124
    Consensus CDS
    CCDS29963.1
    UniProtKB/TrEMBL
    Q3UL16
    UniProtKB/TrEMBL
    Q8C6W8
    UniProtKB/Swiss-Prot
    Q9WVD4
    Conserved Domains (3) summary
    COG0517
    Location:583729
    COG0517; FOG: CBS domain [General function prediction only]
    cd03684
    Location:72570
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:595731
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    7153810..7319364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527562.1XP_006527625.1  

    See proteins identical to XP_006527625.1

    Related
    ENSMUSP00000004428, OTTMUSP00000017743, ENSMUST00000004428, OTTMUST00000039773
    Conserved Domains (3) summary
    COG0517
    Location:665811
    COG0517; FOG: CBS domain [General function prediction only]
    cd03684
    Location:154652
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:677813
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
  2. XM_006527563.1XP_006527626.1  

    See proteins identical to XP_006527626.1

    Conserved Domains (3) summary
    COG0517
    Location:665811
    COG0517; FOG: CBS domain [General function prediction only]
    cd03684
    Location:154652
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...
    cd04591
    Location:677813
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
  3. XM_006527564.1XP_006527627.1  

    Conserved Domains (1) summary
    cd03684
    Location:154531
    ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    4152191..4305907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NW_001036298.1 

    Range
    460..13455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)