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LARP7 La ribonucleoprotein domain family, member 7 [ Homo sapiens (human) ]

Gene ID: 51574, updated on 7-Aug-2014
Official Symbol
LARP7provided by HGNC
Official Full Name
La ribonucleoprotein domain family, member 7provided by HGNC
Primary source
HGNC:24912
Locus tag
HDCMA18P
See related
Ensembl:ENSG00000174720; HPRD:17095; MIM:612026; Vega:OTTHUMG00000132909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALAZS; PIP7S; HDCMA18P
Summary
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
See LARP7 in Epigenomics, MapViewer
Location:
4q25
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (112636964..112657592)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113558120..113578748)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929654 Neighboring gene neurogenin 2 Neighboring gene zinc finger, GRF-type containing 1 Neighboring gene microRNA 302d Neighboring gene microRNA 302a Neighboring gene microRNA 302c Neighboring gene microRNA 302b Neighboring gene microRNA 367 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene tryptophan rich basic protein pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
tat TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase PubMed
tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed
tat HIV-1 Tat is identified to have a physical interaction with La ribonucleoprotein domain family, member 7 (LARP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC104360, DKFZp564K112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
la-related protein 7
Names
la-related protein 7
P-TEFb-interaction protein for 7SK stability

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032779.1 

    Range
    5001..25629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267039.1NP_001253968.1  la-related protein 7 isoform 2

    See proteins identical to NP_001253968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer protein (isoform 2).
    Source sequence(s)
    AC106864, BC066945
    Consensus CDS
    CCDS58924.1
    UniProtKB/Swiss-Prot
    Q4G0J3
    Related
    ENSP00000422626, OTTHUMP00000219762, ENST00000509061, OTTHUMT00000363891
    Conserved Domains (3) summary
    cd08032
    Location:37118
    Blast Score: 416
    LARP_7; La RNA-binding domain of La-related protein 7
    cd12290
    Location:133212
    Blast Score: 357
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:461542
    Blast Score: 296
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
  2. NM_015454.2NP_056269.1  la-related protein 7 isoform 1

    See proteins identical to NP_056269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a 5' exon compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AI652351, AL049996, BM979591, CA314598, CN346208
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    Q4G0J3
    Related
    ENSP00000314311, ENST00000324052
    Conserved Domains (3) summary
    cd08032
    Location:30111
    Blast Score: 415
    LARP_7; La RNA-binding domain of La-related protein 7
    cd12290
    Location:126205
    Blast Score: 356
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454535
    Blast Score: 295
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
  3. NM_016648.3NP_057732.2  la-related protein 7 isoform 1

    See proteins identical to NP_057732.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two 5' exons compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC106864, AI652351, AK000274, AL049996, DB270203
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    Q4G0J3
    Related
    ENSP00000344950, OTTHUMP00000163828, ENST00000344442, OTTHUMT00000256417
    Conserved Domains (3) summary
    cd08032
    Location:30111
    Blast Score: 415
    LARP_7; La RNA-binding domain of La-related protein 7
    cd12290
    Location:126205
    Blast Score: 356
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454535
    Blast Score: 295
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

RNA

  1. NR_049768.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks alternate 5' exons and uses an alternate splice site in a 5' exon compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC106864, BX647100

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    112636964..112657592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    109286524..109307168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    113534600..113555241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)