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PGAM1 phosphoglycerate mutase 1 (brain) [ Homo sapiens (human) ]

Gene ID: 5223, updated on 17-May-2015
Official Symbol
PGAM1provided by HGNC
Official Full Name
phosphoglycerate mutase 1 (brain)provided by HGNC
Primary source
HGNC:HGNC:8888
See related
Ensembl:ENSG00000171314; HPRD:01392; MIM:172250; Vega:OTTHUMG00000018846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGAMA; PGAM-B; HEL-S-35
Summary
Phosphoglyceric acid mutase (EC 2.7.5.3) is widely distributed in mammalian tissues where it catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway (summary by Chen et al., 1974 [PubMed 4811757]).[supplied by OMIM, Nov 2010]
Orthologs
See PGAM1 in MapViewer
Location:
10q25.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (97426270..97433441)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99186027..99193198)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 12 homolog (S. cerevisiae) Neighboring gene ribosomal protein L34 pseudogene 20 Neighboring gene uncharacterized LOC644215 Neighboring gene exosome component 1 Neighboring gene zinc finger, DHHC-type containing 16

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bisphosphoglycerate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
bisphosphoglycerate mutase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoglycerate mutase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphoglycerate mutase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphoglycerate mutase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis TAS
Traceable Author Statement
more info
 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
glucose metabolic process TAS
Traceable Author Statement
more info
 
glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
respiratory burst IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phosphoglycerate mutase 1
Names
phosphoglycerate mutase 1
BPG-dependent PGAM 1
epididymis secretory protein Li 35
phosphoglycerate mutase A, nonmuscle form
phosphoglycerate mutase isozyme B
NP_002620.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002629.2NP_002620.1  phosphoglycerate mutase 1

    See identical proteins and their annotated locations for NP_002620.1

    Status: PROVISIONAL

    Source sequence(s)
    BC010038
    Consensus CDS
    CCDS7458.1
    UniProtKB/Swiss-Prot
    P18669
    UniProtKB/TrEMBL
    Q6FHU2
    Related
    ENSP00000359991, OTTHUMP00000020190, ENST00000334828, OTTHUMT00000049652
    Conserved Domains (1) summary
    cd07067
    Location:5228
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    97426270..97433441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    99467767..99474938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)