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Ctnnb1 catenin (cadherin associated protein), beta 1 [ Mus musculus (house mouse) ]

Gene ID: 12387, updated on 23-Jul-2014
Official Symbol
Ctnnb1provided by MGI
Official Full Name
catenin (cadherin associated protein), beta 1provided by MGI
Primary source
MGI:88276
See related
Ensembl:ENSMUSG00000006932; Vega:OTTMUSG00000016490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bfc; Mesc; Catnb
Summary
This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]
See Ctnnb1 in Epigenomics, MapViewer
Location:
9 F4; 9 72.19 cM
Exon count:
16
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (120933400..120960507)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020M21 gene Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene uncharacterized LOC102637827 Neighboring gene microRNA mir-7090 Neighboring gene uncharacterized LOC102638362 Neighboring gene unc-51-like kinase 4 Neighboring gene zinc finger protein 606 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
alpha-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
alpha-catenin binding IPI
Inferred from Physical Interaction
more info
 
alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IGI
Inferred from Genetic Interaction
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Schwann cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
Schwann cell proliferation ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adherens junction assembly ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone resorption IGI
Inferred from Genetic Interaction
more info
PubMed 
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway involved in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell proliferation TAS
Traceable Author Statement
more info
 
cardiac vascular smooth muscle cell differentiation TAS
Traceable Author Statement
more info
 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell maturation IDA
Inferred from Direct Assay
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis involved in differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular process IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to indole-3-methanol ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
coronary artery morphogenesis TAS
Traceable Author Statement
more info
 
cytoskeletal anchoring at plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ectoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic axis specification IDA
Inferred from Direct Assay
more info
PubMed 
embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic forelimb morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal limb joint morphogenesis IGI
Inferred from Genetic Interaction
more info
 
endoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endodermal cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
epicardium-derived cardiac vascular smooth muscle cell differentiation TAS
Traceable Author Statement
more info
 
epithelial cell differentiation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fungiform papilla formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell fate determination IDA
Inferred from Direct Assay
more info
PubMed 
hair cycle process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
hair follicle placode formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
hindbrain development IBA
Inferred from Biological aspect of Ancestor
more info
 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
layer formation in cerebral cortex IMP
Inferred from Mutant Phenotype
more info
 
lens morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development IBA
Inferred from Biological aspect of Ancestor
more info
 
lung cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung-associated mesenchyme development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal cell proliferation involved in lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
mesenchyme development TAS
Traceable Author Statement
more info
 
mesenchyme morphogenesis TAS
Traceable Author Statement
more info
 
metanephros morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 
negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of heart induction by canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of neuron death IGI
Inferred from Genetic Interaction
more info
 
negative regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
nephron tubule formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural plate development IDA
Inferred from Direct Assay
more info
 
neuron migration IGI
Inferred from Genetic Interaction
more info
 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte development IGI
Inferred from Genetic Interaction
more info
 
organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oviduct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
patterning of blood vessels IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of determination of dorsal identity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
 
positive regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 
regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
 
regulation of centromeric sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 
regulation of centromeric sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
regulation of secondary heart field cardioblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
renal inner medulla development IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal outer medulla development IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal vesicle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to estrogen IBA
Inferred from Biological aspect of Ancestor
more info
 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
single organismal cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
single organismal cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
trachea formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
trachea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular compact myocardium morphogenesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Scrib-APC-beta-catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction ISO
Inferred from Sequence Orthology
more info
 
apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
beta-catenin-TCF7L2 complex ISO
Inferred from Sequence Orthology
more info
 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
catenin complex ISO
Inferred from Sequence Orthology
more info
 
catenin-TCF7L2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft IBA
Inferred from Biological aspect of Ancestor
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
desmosome IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
fascia adherens IDA
Inferred from Direct Assay
more info
PubMed 
intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
tight junction IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
zonula adherens IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
catenin beta-1
Names
catenin beta-1
beta-catenin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165902.1NP_001159374.1  catenin beta-1

    See proteins identical to NP_001159374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC145731, BC048153
    Consensus CDS
    CCDS23630.1
    UniProtKB/Swiss-Prot
    Q02248
    Related
    ENSMUSP00000136294, ENSMUST00000178812
    Conserved Domains (2) summary
    smart00185
    Location:350390
    Blast Score: 109
    ARM; Armadillo/beta-catenin-like repeats
    cd00020
    Location:399518
    Blast Score: 221
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
  2. NM_007614.3NP_031640.1  catenin beta-1

    See proteins identical to NP_031640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC053065, BY766878
    Consensus CDS
    CCDS23630.1
    UniProtKB/Swiss-Prot
    Q02248
    Related
    ENSMUSP00000007130, OTTMUSP00000017750, ENSMUST00000007130, OTTMUST00000039790
    Conserved Domains (2) summary
    smart00185
    Location:350390
    Blast Score: 109
    ARM; Armadillo/beta-catenin-like repeats
    cd00020
    Location:399518
    Blast Score: 221
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    120933400..120960507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511927.1XP_006511990.1  

    See proteins identical to XP_006511990.1

    UniProtKB/Swiss-Prot
    Q02248
    Conserved Domains (2) summary
    smart00185
    Location:350390
    Blast Score: 109
    ARM; Armadillo/beta-catenin-like repeats
    cd00020
    Location:399518
    Blast Score: 221
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    121404098..121431499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)