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SVIL supervillin [ Homo sapiens (human) ]

Gene ID: 6840, updated on 19-Jul-2014
Official Symbol
SVILprovided by HGNC
Official Full Name
supervillinprovided by HGNC
Primary source
HGNC:11480
Locus tag
RP11-534G20.1
See related
Ensembl:ENSG00000197321; HPRD:04992; MIM:604126; Vega:OTTHUMG00000017882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Jul 2008]
See SVIL in Epigenomics, MapViewer
Location:
10p11.2
Exon count:
46
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (29457338..29736935, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (29746274..30025864, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929236 Neighboring gene lysozyme-like 1 Neighboring gene uncharacterized LOC102724316 Neighboring gene microRNA 604 Neighboring gene microRNA 938 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 2 Neighboring gene uncharacterized LOC102724333 Neighboring gene KIAA1462

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686A17191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
actin cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
costamere IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
invadopodium IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
podosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
supervillin
Names
supervillin
p205/p250
archvillin
membrane-associated F-actin binding protein p205

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033998.1 

    Range
    5001..283454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003174.3NP_003165.2  supervillin isoform 1

    See proteins identical to NP_003165.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is alternatively spliced in the 5' portion of the gene, resulting in the shorter isoform (1) which has a different amino-terminus compared to isoform 2.
    Source sequence(s)
    AF051850, AF051851, AI028650, AL160060, BC092440, BX457194
    Consensus CDS
    CCDS7163.1
    UniProtKB/Swiss-Prot
    O95425
    UniProtKB/TrEMBL
    Q569J5
    Related
    ENSP00000364549, OTTHUMP00000019388, ENST00000375400, OTTHUMT00000047393
    Conserved Domains (6) summary
    smart00153
    Location:17531788
    Blast Score: 166
    VHP; Villin headpiece domain
    cd11280
    Location:11371237
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:14531558
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:10161112
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:13201433
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:15751697
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  2. NM_021738.2NP_068506.2  supervillin isoform 2

    See proteins identical to NP_068506.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced in the 5' portion of the gene, resulting in the longer, muscle-specific isoform (2) which has a different amino-terminus compared to isoform 1.
    Source sequence(s)
    AF051850, AF051851, AF109135, AI028650, AL160060, BC092440, BX457194
    Consensus CDS
    CCDS7164.1
    UniProtKB/Swiss-Prot
    O95425
    UniProtKB/TrEMBL
    Q569J5
    Related
    ENSP00000348128, OTTHUMP00000019389, ENST00000355867, OTTHUMT00000047395
    Conserved Domains (6) summary
    smart00153
    Location:21792214
    Blast Score: 168
    VHP; Villin headpiece domain
    cd11280
    Location:15631663
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:18791984
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14421538
    Blast Score: 324
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17461859
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20012123
    Blast Score: 159
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    29457338..29736935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252570.2XP_005252627.1  

    See proteins identical to XP_005252627.1

    Conserved Domains (6) summary
    smart00153
    Location:22212256
    Blast Score: 168
    VHP; Villin headpiece domain
    cd11280
    Location:16051705
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19212026
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14841580
    Blast Score: 324
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17881901
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20432165
    Blast Score: 159
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  2. XM_005252571.2XP_005252628.1  

    See proteins identical to XP_005252628.1

    Conserved Domains (6) summary
    smart00153
    Location:22212256
    Blast Score: 168
    VHP; Villin headpiece domain
    cd11280
    Location:16051705
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19212026
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14841580
    Blast Score: 324
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17881901
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20432165
    Blast Score: 159
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  3. XM_005252572.2XP_005252629.1  

    See proteins identical to XP_005252629.1

    Conserved Domains (6) summary
    smart00153
    Location:22212256
    Blast Score: 168
    VHP; Villin headpiece domain
    cd11280
    Location:16051705
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19212026
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14841580
    Blast Score: 324
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17881901
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20432165
    Blast Score: 159
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  4. XM_005252573.2XP_005252630.1  

    See proteins identical to XP_005252630.1

    Conserved Domains (6) summary
    smart00153
    Location:22212256
    Blast Score: 168
    VHP; Villin headpiece domain
    cd11280
    Location:16051705
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19212026
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14841580
    Blast Score: 324
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17881901
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20432165
    Blast Score: 159
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  5. XM_006717492.1XP_006717555.1  

    Conserved Domains (6) summary
    smart00153
    Location:22932328
    Blast Score: 167
    VHP; Villin headpiece domain
    cd11280
    Location:16771777
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19932098
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:15561652
    Blast Score: 324
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:18601973
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:21152237
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  6. XM_006717496.1XP_006717559.1  

    Conserved Domains (5) summary
    smart00153
    Location:18311866
    Blast Score: 164
    VHP; Villin headpiece domain
    cd11280
    Location:12151315
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:15311636
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:10941186
    Blast Score: 322
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:13981511
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  7. XM_006717495.1XP_006717558.1  

    Conserved Domains (6) summary
    smart00153
    Location:18731908
    Blast Score: 165
    VHP; Villin headpiece domain
    cd11280
    Location:12571357
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:15731678
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:11361232
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:14401553
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:16951817
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  8. XM_006717494.1XP_006717557.1  

    Conserved Domains (6) summary
    smart00153
    Location:19051940
    Blast Score: 166
    VHP; Villin headpiece domain
    cd11280
    Location:12891389
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:16051710
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:11681264
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:14721585
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:17271849
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  9. XM_006717493.1XP_006717556.1  

    Conserved Domains (6) summary
    smart00153
    Location:19892024
    Blast Score: 165
    VHP; Villin headpiece domain
    cd11280
    Location:13731473
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:16891794
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:12521348
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:15561669
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:18111933
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  10. XM_005252568.2XP_005252625.1  

    Conserved Domains (6) summary
    smart00153
    Location:22422277
    Blast Score: 167
    VHP; Villin headpiece domain
    cd11280
    Location:16261726
    Blast Score: 204
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19422047
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:15051601
    Blast Score: 324
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:18091922
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20642186
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  11. XM_005252569.2XP_005252626.1  

    Conserved Domains (6) summary
    smart00153
    Location:22252260
    Blast Score: 165
    VHP; Villin headpiece domain
    cd11280
    Location:16091709
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19252030
    Blast Score: 269
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:14881584
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:17921905
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20472169
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  12. XM_005252566.2XP_005252623.1  

    Conserved Domains (6) summary
    smart00153
    Location:22672302
    Blast Score: 166
    VHP; Villin headpiece domain
    cd11280
    Location:16511751
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19672072
    Blast Score: 269
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:15301626
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:18341947
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20892211
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  13. XM_005252567.2XP_005252624.1  

    Conserved Domains (6) summary
    smart00153
    Location:22572292
    Blast Score: 166
    VHP; Villin headpiece domain
    cd11280
    Location:16411741
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19572062
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:15201616
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:18241937
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20792201
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  14. XM_005252565.2XP_005252622.1  

    Conserved Domains (6) summary
    smart00153
    Location:22732308
    Blast Score: 166
    VHP; Villin headpiece domain
    cd11280
    Location:16571757
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19732078
    Blast Score: 269
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:15361632
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:18401953
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:20952217
    Blast Score: 158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  15. XM_005252564.2XP_005252621.1  

    Conserved Domains (6) summary
    smart00153
    Location:22992334
    Blast Score: 166
    VHP; Villin headpiece domain
    cd11280
    Location:16831783
    Blast Score: 203
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:19992104
    Blast Score: 270
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:15621658
    Blast Score: 323
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:18661979
    Blast Score: 399
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:21212243
    Blast Score: 159
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    29465586..29744249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    29746277..30024634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)