Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    COMT catechol-O-methyltransferase [ Homo sapiens (human) ]

    Gene ID: 1312, updated on 26-Jul-2015
    Official Symbol
    COMTprovided by HGNC
    Official Full Name
    catechol-O-methyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:2228
    See related
    Ensembl:ENSG00000093010; HPRD:00284; MIM:116790; Vega:OTTHUMG00000150529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HEL-S-98n
    Summary
    Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
    Orthologs
    See COMT in Epigenomics, MapViewer
    Location:
    22q11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (19941740..19969975)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19929263..19957498)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene thioredoxin reductase 2 Neighboring gene ribosomal protein L8 pseudogene 5 Neighboring gene uncharacterized LOC105377185 Neighboring gene microRNA 4761 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA 185 Neighboring gene microRNA 3618 Neighboring gene DGCR8 microprocessor complex subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Panic disorder 1
    MedGen: C1868649 OMIM: 167870 GeneReviews: Not available
    Compare labs
    Schizophrenia
    MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with catechol-O-methyltransferase (COMT) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • Biogenic Amine Synthesis, organism-specific biosystem (from WikiPathways)
      Biogenic Amine Synthesis, organism-specific biosystemBiogenic amines are one of two broad classes of classical neurotransmitters (the other being amino acids) and include: acetylcholine, serotonin, histamine, and the catecholamines epinephrine, norepin...
    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Dopamine clearance from the synaptic cleft, organism-specific biosystem (from REACTOME)
      Dopamine clearance from the synaptic cleft, organism-specific biosystemThe human gene SLC6A3 encodes the sodium-dependent dopamine transporter, DAT which mediates the re-uptake of dopamine from the synaptic cleft (Vandenbergh DJ et al, 2000). Dopamine can then be degrad...
    • Dopamine metabolism, organism-specific biosystem (from WikiPathways)
      Dopamine metabolism, organism-specific biosystem
      Dopamine metabolism
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Enzymatic degradation of Dopamine by monoamine oxidase, organism-specific biosystem (from REACTOME)
      Enzymatic degradation of Dopamine by monoamine oxidase, organism-specific biosystemAlternately dopamine is metabolized to homovanillic acid in a two-step reaction in which dopamine is first oxidized to 3,4-dihydroxypheylacetic acid (DOPAC) and then converted to homovanillic acid by...
    • Enzymatic degradation of dopamine by COMT, organism-specific biosystem (from REACTOME)
      Enzymatic degradation of dopamine by COMT, organism-specific biosystemDopamine once taken up by the dopamine transporter from the extracellular space into the cytosol is metabolized in a two step reaction to homovanillic acid.The first reaction is catalyzed by catechol...
    • Estrogen metabolism, organism-specific biosystem (from WikiPathways)
      Estrogen metabolism, organism-specific biosystem
      Estrogen metabolism
    • L-dopa degradation, organism-specific biosystem (from BIOCYC)
      L-dopa degradation, organism-specific biosystemGeneral Background The major pathway of : L-DIHYDROXY-PHENYLALANINE metabolism involves its role as a precursor metabolite in the biosynthesis of the catecholamines : DOPAMINE, : NOREPINEPHRINE and ...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Methylation, organism-specific biosystem (from REACTOME)
      Methylation, organism-specific biosystemMethylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the ...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Clearance In The Synaptic Cleft, organism-specific biosystem (from REACTOME)
      Neurotransmitter Clearance In The Synaptic Cleft, organism-specific biosystemNeurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synapti...
    • Phase II conjugation, organism-specific biosystem (from REACTOME)
      Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
    • Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
      Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
    • Steroid hormone biosynthesis, conserved biosystem (from KEGG)
      Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • Tyrosine metabolism, organism-specific biosystem (from KEGG)
      Tyrosine metabolism, organism-specific biosystem
      Tyrosine metabolism
    • Tyrosine metabolism, conserved biosystem (from KEGG)
      Tyrosine metabolism, conserved biosystem
      Tyrosine metabolism
    • dopamine degradation, organism-specific biosystem (from BIOCYC)
      dopamine degradation, organism-specific biosystemThe catecholamines dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine) function as neurotransmitters and hormones. They have important physiological regulatory roles and are invo...
    • dopamine degradation, conserved biosystem (from BIOCYC)
      dopamine degradation, conserved biosystemThe catecholamines dopamine, noradrenaline (norepinephrine), and adrenaline (epinephrine) function as neurotransmitters and hormones. They have important physiological regulatory roles and are invo...
    • metapathway biotransformation, organism-specific biosystem (from WikiPathways)
      metapathway biotransformation, organism-specific biosystem
      metapathway biotransformation
    • noradrenaline and adrenaline degradation, organism-specific biosystem (from BIOCYC)
      noradrenaline and adrenaline degradation, organism-specific biosystemGeneral Background The catecholamines : DOPAMINE, : NOREPINEPHRINE (norepinephrine), and : L-EPINEPHRINE (epinephrine) function as neurotransmitters and hormones. They have important physiological ...
    • noradrenaline and adrenaline degradation, conserved biosystem (from BIOCYC)
      noradrenaline and adrenaline degradation, conserved biosystemGeneral Background The catecholamines |FRAME: DOPAMINE|, |FRAME: NOREPINEPHRINE| (norepinephrine), and |FRAME: L-EPINEPHRINE| (epinephrine) function as neurotransmitters and hormones. They have imp...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    O-methyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    catechol O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to phosphate starvation IEA
    Inferred from Electronic Annotation
    more info
     
    developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    dopamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    methylation TAS
    Traceable Author Statement
    more info
     
    multicellular organismal reproductive process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter biosynthetic process TAS
    Traceable Author Statement
    more info
     
    neurotransmitter catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of homocysteine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    short-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    synaptic transmission TAS
    Traceable Author Statement
    more info
     
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    catechol O-methyltransferase
    Names
    catechol-O-methyltransferase isoform
    epididymis secretory sperm binding protein Li 98n
    NP_000745.1
    NP_001128633.1
    NP_001128634.1
    NP_009294.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011526.1 RefSeqGene

      Range
      5001..33236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000754.3NP_000745.1  catechol O-methyltransferase isoform MB-COMT

      See identical proteins and their annotated locations for NP_000745.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as MB-COMT) represents the longest transcript and encodes the longer isoform (MB-COMT). Variants 1, 2, and 3 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
      Source sequence(s)
      AC005663, AK290440, BX461394
      Consensus CDS
      CCDS13770.1
      UniProtKB/Swiss-Prot
      P21964
      Related
      ENSP00000354511, OTTHUMP00000197846, ENST00000361682, OTTHUMT00000318936
      Conserved Domains (1) summary
      cd02440
      Location:112217
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001135161.1NP_001128633.1  catechol O-methyltransferase isoform MB-COMT

      See identical proteins and their annotated locations for NP_001128633.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
      Source sequence(s)
      AC005663, AK290440, BE386545
      Consensus CDS
      CCDS13770.1
      UniProtKB/Swiss-Prot
      P21964
      Conserved Domains (1) summary
      cd02440
      Location:112217
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001135162.1NP_001128634.1  catechol O-methyltransferase isoform MB-COMT

      See identical proteins and their annotated locations for NP_001128634.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
      Source sequence(s)
      AC005663, AK290440, BE728779
      Consensus CDS
      CCDS13770.1
      UniProtKB/Swiss-Prot
      P21964
      Conserved Domains (1) summary
      cd02440
      Location:112217
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. NM_007310.2NP_009294.1  catechol O-methyltransferase isoform S-COMT

      See identical proteins and their annotated locations for NP_009294.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as S-COMT) contains a shorter 5' UTR and a translation start site which lies 50 codons downstream compared to that of variant 1. The resulting isoform (S-COMT) is shorter at the N-terminus compared to isoform MB-COMT. S-COMT is a soluble protein.
      Source sequence(s)
      AC005663, AK290440
      Consensus CDS
      CCDS46663.1
      UniProtKB/Swiss-Prot
      P21964
      Conserved Domains (1) summary
      cd02440
      Location:62167
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

      Range
      19941740..19969975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529887.1XP_011528189.1  

      See identical proteins and their annotated locations for XP_011528189.1

      Conserved Domains (1) summary
      cd02440
      Location:112197
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_011529890.1XP_011528192.1  

      See identical proteins and their annotated locations for XP_011528192.1

      Conserved Domains (1) summary
      cd02440
      Location:112197
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_011529891.1XP_011528193.1  

      See identical proteins and their annotated locations for XP_011528193.1

      Conserved Domains (1) summary
      cd02440
      Location:112197
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_011529889.1XP_011528191.1  

      See identical proteins and their annotated locations for XP_011528191.1

      Conserved Domains (1) summary
      cd02440
      Location:112197
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. XM_011529888.1XP_011528190.1  

      See identical proteins and their annotated locations for XP_011528190.1

      Conserved Domains (1) summary
      cd02440
      Location:112197
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    6. XM_011529886.1XP_011528188.1  

      Related
      ENSP00000385150, OTTHUMP00000197748, ENST00000406520, OTTHUMT00000318770
      Conserved Domains (1) summary
      cd02440
      Location:150255
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    7. XM_011529885.1XP_011528187.1  

      Conserved Domains (1) summary
      cd02440
      Location:150235
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      19929027..19957208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)