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    Zfp423 zinc finger protein 423 [ Mus musculus (house mouse) ]

    Gene ID: 94187, updated on 20-Aug-2016
    Official Symbol
    Zfp423provided by MGI
    Official Full Name
    zinc finger protein 423provided by MGI
    Primary source
    MGI:MGI:1891217
    See related
    Ensembl:ENSMUSG00000045333 Vega:OTTMUSG00000036956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Roaz; Ebfaz; nur12; Zfp104; Znf423; ataxia1; mKIAA0760
    Orthologs
    Location:
    8; 8 C4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (87661810..87959595, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (90185709..90483494, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933402J07 gene Neighboring gene RIKEN cDNA 1700096P03 gene Neighboring gene predicted gene, 34412 Neighboring gene predicted gene, 42032 Neighboring gene predicted gene, 39217

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    zinc finger protein 423
    Names
    early B-cell factor associated zinc finger protein
    early B-cell factor associated zinc finger transcription factor
    early B-cell factor-associated zinc finger protein
    olf1/EBF-associated zinc finger protein
    smad- and Olf-interacting zinc finger protein
    zinc finger protein 104

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310520.1NP_001297449.1  zinc finger protein 423 isoform 2

      See identical proteins and their annotated locations for NP_001297449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI845255, AK133497, BC079586
      Consensus CDS
      CCDS80911.1
      UniProtKB/TrEMBL
      G3UW89, Q3V017
      Related
      ENSMUSP00000129724, OTTMUSP00000052950, ENSMUST00000165770, OTTMUST00000094958
      Conserved Domains (2) summary
      COG5048
      Location:77478
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:2343
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_033327.2NP_201584.2  zinc finger protein 423 isoform 1

      See identical proteins and their annotated locations for NP_201584.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK122365, BB788751, BF021428, BQ180174, BU519630
      Consensus CDS
      CCDS52627.1
      UniProtKB/Swiss-Prot
      Q80TS5
      Related
      ENSMUSP00000105282, OTTMUSP00000052951, ENSMUST00000109655, OTTMUST00000094959
      Conserved Domains (2) summary
      COG5048
      Location:202603
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:148168
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      87661810..87959595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248560.2XP_011246862.1  

      Conserved Domains (2) summary
      COG5048
      Location:222623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:168188
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_017313033.1XP_017168522.1  

    3. XM_006531539.3XP_006531602.1  

      See identical proteins and their annotated locations for XP_006531602.1

      UniProtKB/TrEMBL
      G3UW89
      Conserved Domains (2) summary
      COG5048
      Location:77478
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:2343
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_011248561.2XP_011246863.1  

      See identical proteins and their annotated locations for XP_011246863.1

      UniProtKB/TrEMBL
      G3UW89
      Conserved Domains (2) summary
      COG5048
      Location:77478
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:2343
      ZF_C2H2; C2H2 Zn finger [structural motif]