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    ST14 suppression of tumorigenicity 14 [ Homo sapiens (human) ]

    Gene ID: 6768, updated on 9-Jun-2016
    Official Symbol
    ST14provided by HGNC
    Official Full Name
    suppression of tumorigenicity 14provided by HGNC
    Primary source
    HGNC:HGNC:11344
    See related
    Ensembl:ENSG00000149418 HPRD:06005; MIM:606797; Vega:OTTHUMG00000165768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HAI; MTSP1; SNC19; ARCI11; MT-SP1; PRSS14; TADG15; TMPRSS14
    Summary
    The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q24-q25
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (130159787..130210362)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (130029682..130080257)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984432 Neighboring gene amyloid beta precursor like protein 2 Neighboring gene ribosomal protein L34 pseudogene 21 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 2 pseudogene Neighboring gene DEAD-box helicase 18 pseudogene 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env Matriptase, a serine protease, efficiently cleaves the HR1 portion of HIV-1 gp41 into a 22-residue chemotactic peptide MAT-1, leading to chemotaxis by using FPR2 in primary neutrophils PubMed

    Go to the HIV-1, Human Interaction Database

    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: APLP2

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    epithelial cell morphogenesis involved in placental branching IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    suppressor of tumorigenicity 14 protein
    Names
    membrane-type serine protease 1
    prostamin
    serine protease 14
    serine protease TADG-15
    suppression of tumorigenicity 14 (colon carcinoma)
    suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
    tumor associated differentially expressed gene 15 protein
    tumor-associated differentially-expressed gene 15 protein
    NP_068813.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012132.1 RefSeqGene

      Range
      5001..55576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021978.3NP_068813.1  suppressor of tumorigenicity 14 protein

      See identical proteins and their annotated locations for NP_068813.1

      Status: REVIEWED

      Source sequence(s)
      AB030036, BC005826, BM791311
      Consensus CDS
      CCDS8487.1
      UniProtKB/Swiss-Prot
      Q9Y5Y6
      Related
      ENSP00000278742, OTTHUMP00000230931, ENST00000278742, OTTHUMT00000386119
      Conserved Domains (5) summary
      smart00020
      Location:614849
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:340444
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:525559
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:615852
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:85193
      SEA; SEA domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      130159787..130210362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      129915529..129966064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)