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    Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus (house mouse) ]

    Gene ID: 16151, updated on 22-Aug-2016
    Official Symbol
    Ikbkgprovided by MGI
    Official Full Name
    inhibitor of kappaB kinase gammaprovided by MGI
    Primary source
    MGI:MGI:1338074
    See related
    Ensembl:ENSMUSG00000004221 Vega:OTTMUSG00000017732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
    Orthologs
    Location:
    X; X A7.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (74393291..74456792)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71638630..71699117)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene predicted gene 6880 Neighboring gene ribosomal protein S2 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    K63-linked polyubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    linear polyubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    IkappaB kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    IkappaB kinase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NF-kappa-B essential modulator
    Names
    I-kappa-B kinase subunit gamma
    IKK-gamma
    IKKAP1
    IKKG
    NF-kappa-B essential modifier
    ikB kinase subunit gamma
    ikB kinase-associated protein 1
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    inhibitor of nuclear factor kappa-B kinase subunit gamma
    mFIP-3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136067.2NP_001129539.1  NF-kappa-B essential modulator isoform 3

      See identical proteins and their annotated locations for NP_001129539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL669976, AY112937
      Consensus CDS
      CCDS53108.1
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000004330, ENSMUST00000004330
      Conserved Domains (3) summary
      cd09803
      Location:269355
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:62129
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:186298
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    2. NM_001161421.1NP_001154893.1  NF-kappa-B essential modulator isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
      Source sequence(s)
      AK037020, AL669976, AY112937
      UniProtKB/TrEMBL
      Q7TSS3, Q8VC91
      Conserved Domains (2) summary
      pfam11577
      Location:62129
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:268354
      UBAN; polyubiquitin binding domain of NEMO and related proteins
    3. NM_001161422.1NP_001154894.1  NF-kappa-B essential modulator isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AL669976, AY112937, CN701499
      Consensus CDS
      CCDS53109.1
      UniProtKB/TrEMBL
      E9Q2Y3, Q7TSS3
      Related
      ENSMUSP00000109765, ENSMUST00000114130
      Conserved Domains (3) summary
      cd09803
      Location:263349
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:56123
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:180292
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    4. NM_001161423.1NP_001154895.1  NF-kappa-B essential modulator isoform 1

      See identical proteins and their annotated locations for NP_001154895.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CN717929
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000126770, ENSMUST00000164101
      Conserved Domains (3) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:168280
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    5. NM_001161424.1NP_001154896.1  NF-kappa-B essential modulator isoform 2

      See identical proteins and their annotated locations for NP_001154896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CV556906
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000136573, ENSMUST00000180230
      Conserved Domains (3) summary
      cd09803
      Location:250336
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:167279
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    6. NM_010547.2NP_034677.2  NF-kappa-B essential modulator isoform 1

      See identical proteins and their annotated locations for NP_034677.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AL669976, AY112937, BY768708
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000109762, OTTMUSP00000021360, ENSMUST00000114127, OTTMUST00000047324
      Conserved Domains (3) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:168280
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    7. NM_178590.4NP_848705.1  NF-kappa-B essential modulator isoform 2

      See identical proteins and their annotated locations for NP_848705.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, BY768708
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000064017, OTTMUSP00000021361, ENSMUST00000064407, OTTMUST00000047325
      Conserved Domains (3) summary
      cd09803
      Location:250336
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:167279
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      74393291..74456792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527852.2XP_006527915.1  

      See identical proteins and their annotated locations for XP_006527915.1

      UniProtKB/Swiss-Prot
      O88522
      Conserved Domains (3) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:168280
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    2. XM_006527848.3XP_006527911.1  

      See identical proteins and their annotated locations for XP_006527911.1

      UniProtKB/TrEMBL
      Q7TSS3
      Conserved Domains (3) summary
      cd09803
      Location:269355
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:62129
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:186298
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    3. XM_006527847.3XP_006527910.1  

      See identical proteins and their annotated locations for XP_006527910.1

      UniProtKB/TrEMBL
      Q7TSS3
      Conserved Domains (3) summary
      cd09803
      Location:269355
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:62129
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:186298
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    4. XM_006527853.3XP_006527916.1  

      See identical proteins and their annotated locations for XP_006527916.1

      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000109764, OTTMUSP00000021357, ENSMUST00000114129, OTTMUST00000047321
      Conserved Domains (3) summary
      cd09803
      Location:250336
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:167279
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    5. XM_006527850.2XP_006527913.1  

      See identical proteins and their annotated locations for XP_006527913.1

      UniProtKB/Swiss-Prot
      O88522
      Related
      ENSMUSP00000109763, OTTMUSP00000021358, ENSMUST00000114128, OTTMUST00000047322
      Conserved Domains (3) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:168280
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    6. XM_006527851.2XP_006527914.1  

      See identical proteins and their annotated locations for XP_006527914.1

      UniProtKB/Swiss-Prot
      O88522
      Conserved Domains (3) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:168280
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    7. XM_006527849.2XP_006527912.1  

      Conserved Domains (2) summary
      pfam11577
      Location:50117
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:257343
      UBAN; polyubiquitin binding domain of NEMO and related proteins
    8. XM_011247527.2XP_011245829.1  

      See identical proteins and their annotated locations for XP_011245829.1

      UniProtKB/Swiss-Prot
      O88522
      Conserved Domains (3) summary
      cd09803
      Location:251337
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      pfam11577
      Location:44111
      NEMO; NF-kappa-B essential modulator NEMO
      cl00459
      Location:168280
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily